Format

Send to:

Choose Destination

DCUN1D5 defective in cullin neddylation 1 domain containing 5 [ Homo sapiens (human) ]

Gene ID: 84259, updated on 21-Dec-2019

Summary

Official Symbol
DCUN1D5provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 5provided by HGNC
Primary source
HGNC:HGNC:28409
See related
Ensembl:ENSG00000137692 MIM:616522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCCRO5
Expression
Ubiquitous expression in brain (RPKM 3.6), fat (RPKM 1.6) and 25 other tissues See more
Orthologs

Genomic context

See DCUN1D5 in Genome Data Viewer
Location:
11q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (103050686..103092215, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102921413..102962944, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 13 Neighboring gene ribosomal protein L21 pseudogene 96 Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene MT-ATP6 pseudogene 15 Neighboring gene MT-CO3 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2714, FLJ32431, FLJ37425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DCN1-like protein 5
Names
DCN1, defective in cullin neddylation 1, domain containing 5
DCUN1 domain-containing protein 5
defective in cullin neddylation protein 1-like protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318739.2NP_001305668.1  DCN1-like protein 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK298227, AP001486
    UniProtKB/TrEMBL
    B4DP84
    Conserved Domains (1) summary
    pfam03556
    Location:51161
    Cullin_binding; Cullin binding
  2. NM_001318740.2NP_001305669.1  DCN1-like protein 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK298227, AP001486, CN261961, DB039638
    UniProtKB/TrEMBL
    B4DP84
    Related
    ENSP00000435035.1, ENST00000531543.1
    Conserved Domains (1) summary
    pfam03556
    Location:7117
    Cullin_binding; Cullin binding
  3. NM_001318741.2NP_001305670.1  DCN1-like protein 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK298227, AP001486, BM723994, DB039638
    UniProtKB/TrEMBL
    B4DP84
    Conserved Domains (1) summary
    pfam03556
    Location:7117
    Cullin_binding; Cullin binding
  4. NM_032299.4NP_115675.1  DCN1-like protein 5 isoform a

    See identical proteins and their annotated locations for NP_115675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AP001486, BC004169, DB039638
    Consensus CDS
    CCDS8325.1
    UniProtKB/Swiss-Prot
    Q9BTE7
    UniProtKB/TrEMBL
    A0A024R3A2
    Related
    ENSP00000260247.5, ENST00000260247.10
    Conserved Domains (1) summary
    pfam03556
    Location:120230
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    103050686..103092215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018404.2XP_016873893.1  DCN1-like protein 5 isoform X1

Support Center