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DCUN1D5 defective in cullin neddylation 1 domain containing 5 [ Homo sapiens (human) ]

Gene ID: 84259, updated on 17-Sep-2024

Summary

Official Symbol
DCUN1D5provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 5provided by HGNC
Primary source
HGNC:HGNC:28409
See related
Ensembl:ENSG00000137692 MIM:616522; AllianceGenome:HGNC:28409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCNL5; SCCRO5
Summary
Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 3.6), fat (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See DCUN1D5 in Genome Data Viewer
Location:
11q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (103050686..103092160, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (103054420..103095887, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102921415..102962889, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:102825894-102827093 Neighboring gene NANOG hESC enhancer GRCh37_chr11:102852196-102852783 Neighboring gene matrix metallopeptidase 13 Neighboring gene ribosomal protein L21 pseudogene 96 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:102962009-102962626 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:102962627-102963244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:103012329-103012830 Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene MT-ATP6 pseudogene 15 Neighboring gene MT-CO3 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
EBI GWAS Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
EBI GWAS Catalog
Genome-wide association study of selenium concentrations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2714, FLJ32431, FLJ37425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DCN1-like protein 5
Names
DCN1, defective in cullin neddylation 1, domain containing 5
DCUN1 domain-containing protein 5
defective in cullin neddylation protein 1-like protein 5
squamous cell carcinoma-related oncogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318739.2NP_001305668.1  DCN1-like protein 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK298227, AP001486
    UniProtKB/TrEMBL
    B4DP84
    Conserved Domains (1) summary
    pfam03556
    Location:51161
    Cullin_binding; Cullin binding
  2. NM_001318740.2NP_001305669.1  DCN1-like protein 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK298227, AP001486, CN261961, DB039638
    UniProtKB/TrEMBL
    B4DP84
    Related
    ENSP00000435035.1, ENST00000531543.1
    Conserved Domains (1) summary
    pfam03556
    Location:7117
    Cullin_binding; Cullin binding
  3. NM_001318741.2NP_001305670.1  DCN1-like protein 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK298227, AP001486, BM723994, DB039638
    UniProtKB/TrEMBL
    B4DP84
    Conserved Domains (1) summary
    pfam03556
    Location:7117
    Cullin_binding; Cullin binding
  4. NM_032299.4NP_115675.1  DCN1-like protein 5 isoform a

    See identical proteins and their annotated locations for NP_115675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AP001486, BC004169, DB039638
    Consensus CDS
    CCDS8325.1
    UniProtKB/Swiss-Prot
    Q3ZTT2, Q9BTE7
    Related
    ENSP00000260247.5, ENST00000260247.10
    Conserved Domains (1) summary
    pfam03556
    Location:120230
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    103050686..103092160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    103054420..103095887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)