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SLF1 SMC5-SMC6 complex localization factor 1 [ Homo sapiens (human) ]

Gene ID: 84250, updated on 17-Jun-2019

Summary

Official Symbol
SLF1provided by HGNC
Official Full Name
SMC5-SMC6 complex localization factor 1provided by HGNC
Primary source
HGNC:HGNC:25408
See related
Ensembl:ENSG00000133302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRCTx; BRCTD1; ANKRD32
Expression
Broad expression in testis (RPKM 3.1), bone marrow (RPKM 1.1) and 23 other tissues See more
Orthologs

Genomic context

See SLF1 in Genome Data Viewer
Location:
5q15
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (94613476..94714918)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (93953086..94033326)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene KIAA0825 Neighboring gene uncharacterized LOC105379086 Neighboring gene FAST kinase domains 1 pseudogene Neighboring gene multiple C2 and transmembrane domain containing 1 Neighboring gene ribosomal protein L7 pseudogene 18 Neighboring gene uncharacterized LOC105379085

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761C121, DKFZp564C0469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SMC5-SMC6 complex localization factor protein 1
Names
BRCT domain containing 1
BRCT domain-containing protein 1
ankyrin repeat domain 32
ankyrin repeat domain-containing protein 32
smc5/6 localization factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032290.4NP_115666.2  SMC5-SMC6 complex localization factor protein 1

    See identical proteins and their annotated locations for NP_115666.2

    Status: VALIDATED

    Source sequence(s)
    AC008534, AC025766, BC063674, BU431750, CR936768, DR001089
    Consensus CDS
    CCDS4071.2
    UniProtKB/Swiss-Prot
    Q9BQI6
    UniProtKB/TrEMBL
    I6L9F1
    Related
    ENSP00000265140.5, ENST00000265140.10
    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    94613476..94714918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009979.2XP_016865468.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9BQI6
    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  2. XM_024446231.1XP_024301999.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  3. XM_024446232.1XP_024302000.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  4. XM_024446233.1XP_024302001.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  5. XM_024446234.1XP_024302002.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:803918
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  6. XM_024446238.1XP_024302006.1  SMC5-SMC6 complex localization factor protein 1 isoform X8

    Conserved Domains (1) summary
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  7. XM_024446235.1XP_024302003.1  SMC5-SMC6 complex localization factor protein 1 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:753868
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:757788
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  8. XM_017009981.2XP_016865470.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

    Conserved Domains (4) summary
    cd00027
    Location:1578
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00204
    Location:779894
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:787880
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:783814
    ANK; ANK repeat [structural motif]
  9. XM_024446236.1XP_024302004.1  SMC5-SMC6 complex localization factor protein 1 isoform X4

    Conserved Domains (3) summary
    cd00204
    Location:803898
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:807838
    ANK; ANK repeat [structural motif]
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  10. XM_024446237.1XP_024302005.1  SMC5-SMC6 complex localization factor protein 1 isoform X5

    Conserved Domains (1) summary
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  11. XM_024446239.1XP_024302007.1  SMC5-SMC6 complex localization factor protein 1 isoform X8

    Conserved Domains (1) summary
    cl00038
    Location:1288
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  12. XM_017009984.1XP_016865473.1  SMC5-SMC6 complex localization factor protein 1 isoform X7

  13. XM_017009983.1XP_016865472.1  SMC5-SMC6 complex localization factor protein 1 isoform X6

    Conserved Domains (3) summary
    cd00204
    Location:344459
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:352445
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:348379
    ANK; ANK repeat [structural motif]
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