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PSD2 pleckstrin and Sec7 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 84249, updated on 4-Oct-2020

Summary

Official Symbol
PSD2provided by HGNC
Official Full Name
pleckstrin and Sec7 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:19092
See related
Ensembl:ENSG00000146005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFA6C
Expression
Biased expression in brain (RPKM 11.2) and testis (RPKM 0.5) See more
Orthologs

Genomic context

See PSD2 in Genome Data Viewer
Location:
5q31.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139711263..139844466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139175406..139224051)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr5.3240 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene CXXC finger protein 5 Neighboring gene RNA, U6 small nuclear 236, pseudogene Neighboring gene PSD2 antisense RNA 1 Neighboring gene neuregulin 2 Neighboring gene mitosis associated long intergenic non-coding RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761B0514

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
PH and SEC7 domain-containing protein 2
Names
exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C
exchange factor for ARF6 C
pleckstrin homology and SEC7 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032289.4NP_115665.1  PH and SEC7 domain-containing protein 2

    See identical proteins and their annotated locations for NP_115665.1

    Status: VALIDATED

    Source sequence(s)
    AC008667, AL136559, BM663376
    Consensus CDS
    CCDS4216.1
    UniProtKB/Swiss-Prot
    Q9BQI7
    Related
    ENSP00000274710.3, ENST00000274710.4
    Conserved Domains (2) summary
    cd00171
    Location:297464
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:510633
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    139711263..139844466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537696.2XP_011535998.1  PH and SEC7 domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd00171
    Location:317484
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:530653
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:550645
    PH; PH domain
  2. XM_017009976.1XP_016865465.1  PH and SEC7 domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9BQI7
    Conserved Domains (2) summary
    cd00171
    Location:297464
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:510633
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
  3. XM_017009977.1XP_016865466.1  PH and SEC7 domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9BQI7
    Conserved Domains (2) summary
    cd00171
    Location:297464
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:510633
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
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