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ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 [ Homo sapiens (human) ]

Gene ID: 84243, updated on 5-May-2024

Summary

Official Symbol
ZDHHC18provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 18provided by HGNC
Primary source
HGNC:HGNC:20712
See related
Ensembl:ENSG00000204160 AllianceGenome:HGNC:20712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC18; DHHC-18
Summary
Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 36.8), appendix (RPKM 14.1) and 24 other tissues See more
Orthologs
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Genomic context

See ZDHHC18 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26826688..26857604)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26664755..26695679)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27153179..27184095)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 519 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27114367-27115193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 521 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class V Neighboring gene ATAC-STARR-seq lymphoblastoid active region 522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27130608-27131323 Neighboring gene RNA, 7SL, cytoplasmic 165, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27152961-27153113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 525 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27179723-27180224 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27181471-27181643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27189325-27190204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 527 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27195686-27195844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:27198339-27199538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27201365-27201864 Neighboring gene stratifin Neighboring gene GPN-loop GTPase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27215935-27216812

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PIGV

Clone Names

  • DKFZp667O2416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC18
Names
DHHC domain-containing cysteine-rich protein 18
zinc finger DHHC domain-containing protein 18
zinc finger DHHC-type containing 18
zinc finger, DHHC domain containing 18
NP_115659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032283.3NP_115659.1  palmitoyltransferase ZDHHC18

    See identical proteins and their annotated locations for NP_115659.1

    Status: VALIDATED

    Source sequence(s)
    AL034380, AL512765, BC066776
    Consensus CDS
    CCDS30650.1
    UniProtKB/Swiss-Prot
    A6NHY9, B4DQ84, Q5JYH0, Q9H020, Q9NUE0
    Related
    ENSP00000363257.3, ENST00000374142.9
    Conserved Domains (1) summary
    pfam01529
    Location:191314
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26826688..26857604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26664755..26695679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)