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MAF1 MAF1 homolog, negative regulator of RNA polymerase III [ Homo sapiens (human) ]

Gene ID: 84232, updated on 1-Jun-2020

Summary

Official Symbol
MAF1provided by HGNC
Official Full Name
MAF1 homolog, negative regulator of RNA polymerase IIIprovided by HGNC
Primary source
HGNC:HGNC:24966
See related
Ensembl:ENSG00000179632 MIM:610210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues See more
Orthologs

Genomic context

See MAF1 in Genome Data Viewer
Location:
8q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144104461..144107611)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145159305..145162515)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cytochrome c1 Neighboring gene SHANK associated RH domain interactor Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene WD repeat domain 97 Neighboring gene HGH1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20332, MGC31779, MGC39758

Gene Ontology Provided by GOA

Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
inhibitory synapse IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
repressor of RNA polymerase III transcription MAF1 homolog
Names
MAF1 negative regulator of RNA polymerase III
homolog of yeast MAF1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032272.5NP_115648.2  repressor of RNA polymerase III transcription MAF1 homolog

    See identical proteins and their annotated locations for NP_115648.2

    Status: REVIEWED

    Source sequence(s)
    BC018714, BC031273, BE093055, BF339064, BM721318, DN997000
    Consensus CDS
    CCDS6416.1
    UniProtKB/Swiss-Prot
    Q9H063
    Related
    ENSP00000318604.5, ENST00000322428.10
    Conserved Domains (1) summary
    pfam09174
    Location:25202
    Maf1; Maf1 regulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144104461..144107611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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