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ZMYND15 zinc finger MYND-type containing 15 [ Homo sapiens (human) ]

Gene ID: 84225, updated on 11-Jun-2021

Summary

Official Symbol
ZMYND15provided by HGNC
Official Full Name
zinc finger MYND-type containing 15provided by HGNC
Primary source
HGNC:HGNC:20997
See related
Ensembl:ENSG00000141497 MIM:614312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF14
Summary
This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Expression
Biased expression in testis (RPKM 15.6), lung (RPKM 3.5) and 10 other tissues See more
Orthologs
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Genomic context

See ZMYND15 in Genome Data Viewer
Location:
17p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4739833..4746119)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4643128..4649414)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arrestin beta 2 Neighboring gene mediator complex subunit 11 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene vitelline membrane outer layer 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434N127

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger MYND domain-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034160.1 RefSeqGene

    Range
    5001..11105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136046.3NP_001129518.1  zinc finger MYND domain-containing protein 15 isoform 1

    See identical proteins and their annotated locations for NP_001129518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC091153, AK302181, DB453494
    Consensus CDS
    CCDS45584.1
    UniProtKB/Swiss-Prot
    Q9H091
    Related
    ENSP00000391742.1, ENST00000433935.6
    Conserved Domains (1) summary
    pfam01753
    Location:313359
    zf-MYND; MYND finger
  2. NM_001267822.1NP_001254751.1  zinc finger MYND domain-containing protein 15 isoform 3

    See identical proteins and their annotated locations for NP_001254751.1

    Status: REVIEWED

    Source sequence(s)
    AA937353, AK302181, BC067296, DB453494
    Consensus CDS
    CCDS58506.1
    UniProtKB/Swiss-Prot
    Q9H091
    Related
    ENSP00000269289.6, ENST00000269289.10
    Conserved Domains (1) summary
    pfam01753
    Location:313359
    zf-MYND; MYND finger
  3. NM_032265.2NP_115641.1  zinc finger MYND domain-containing protein 15 isoform 2

    See identical proteins and their annotated locations for NP_115641.1

    Status: REVIEWED

    Source sequence(s)
    AA937353, AC091153, AL136893, DB453494
    Consensus CDS
    CCDS11053.1
    UniProtKB/Swiss-Prot
    Q9H091
    Related
    ENSP00000465435.1, ENST00000592813.5
    Conserved Domains (1) summary
    pfam01753
    Location:313359
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4739833..4746119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025218.1XP_016880707.1  zinc finger MYND domain-containing protein 15 isoform X1

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