Format

Send to:

Choose Destination

TBC1D3F TBC1 domain family member 3F [ Homo sapiens (human) ]

Gene ID: 84218, updated on 12-Oct-2019

Summary

Official Symbol
TBC1D3Fprovided by HGNC
Official Full Name
TBC1 domain family member 3Fprovided by HGNC
Primary source
HGNC:HGNC:18257
See related
Ensembl:ENSG00000275954 MIM:610809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TBC1D3; TBC1D3G
Annotation information
Note: After build 36.3 (2008), NCBI noted that the annotation of TBC1D3 and TBC1D3F were incorrect. At that time geneID:729873 was renamed to TBC1D3 and geneID:84218 was renamed to TBC1D3F. [22 Apr 2009]
Expression
Broad expression in testis (RPKM 23.1), skin (RPKM 11.4) and 23 other tissues See more

Genomic context

See TBC1D3F in Genome Data Viewer
Location:
17q12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36428612..36439521, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36283868..36294915)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 2, inducible pseudogene Neighboring gene TBC1 domain family member 3H Neighboring gene RNA, U6 small nuclear 1192, pseudogene Neighboring gene TBC1 domain family member 3J Neighboring gene uncharacterized LOC105371749 Neighboring gene zinc finger HIT-type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ56187, FLJ58835, FLJ78569, MGC87892

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 3F
Names
TBC1 domain family member 3
TBC1 domain family member 3G
prostate cancer gene 17 protein
protein TRE17-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032258.5NP_115634.3  TBC1 domain family member 3F

    See identical proteins and their annotated locations for NP_115634.3

    Status: VALIDATED

    Source sequence(s)
    AC233698
    UniProtKB/Swiss-Prot
    A6NER0
    Related
    ENSP00000477679.1, ENST00000620210.1
    Conserved Domains (1) summary
    smart00164
    Location:99312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36428612..36439521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    663516..674425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center