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MEX3B mex-3 RNA binding family member B [ Homo sapiens (human) ]

Gene ID: 84206, updated on 23-Nov-2021

Summary

Official Symbol
MEX3Bprovided by HGNC
Official Full Name
mex-3 RNA binding family member Bprovided by HGNC
Primary source
HGNC:HGNC:25297
See related
Ensembl:ENSG00000183496 MIM:611008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RKHD3; MEX-3B; RNF195
Summary
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]
Expression
Biased expression in testis (RPKM 20.7), endometrium (RPKM 5.5) and 7 other tissues See more
Orthologs
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Genomic context

See MEX3B in Genome Data Viewer
Location:
15q25.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (82041778..82046018, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (82334119..82338359, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370922 Neighboring gene protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene uncharacterized LOC105370923 Neighboring gene uncharacterized LOC105370924 Neighboring gene long intergenic non-protein coding RNA 1583 Neighboring gene elongation factor like GTPase 1 Neighboring gene RNA, U1 small nuclear 77, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
GeneReviews: Not available
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mex-3 homolog B (C. elegans) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117199, DKFZp434J0617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RNA-binding protein MEX3B
Names
RING finger protein 195
ring finger and KH domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032246.6NP_115622.2  RNA-binding protein MEX3B

    See identical proteins and their annotated locations for NP_115622.2

    Status: REVIEWED

    Source sequence(s)
    AC026956
    Consensus CDS
    CCDS10319.1
    UniProtKB/Swiss-Prot
    Q6ZN04
    Related
    ENSP00000329918.4, ENST00000329713.5
    Conserved Domains (3) summary
    smart00322
    Location:160225
    KH; K homology RNA-binding domain
    cd00105
    Location:67127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam13920
    Location:518563
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    82041778..82046018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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