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TXNDC2 thioredoxin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 84203, updated on 17-Jun-2019

Summary

Official Symbol
TXNDC2provided by HGNC
Official Full Name
thioredoxin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:16470
See related
Ensembl:ENSG00000168454 MIM:617790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPTRX; SPTRX1
Expression
Restricted expression toward testis (RPKM 25.5) See more
Orthologs

Genomic context

See TXNDC2 in Genome Data Viewer
Location:
18p11.22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (9885973..9889275)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9885723..9889272)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RAB31, member RAS oncogene family Neighboring gene RNA, 5S ribosomal pseudogene 449 Neighboring gene uncharacterized LOC105371982 Neighboring gene Sharpr-MPRA regulatory region 4522 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P pseudogene 4 Neighboring gene RNA, 5S ribosomal pseudogene 450 Neighboring gene VAMP associated protein A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35026, DKFZp434H0311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
thioredoxin-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thioredoxin domain-containing protein 2
Names
sperm-specific thioredoxin 1
spermatid-specific thioredoxin-1
sptrx-1
testicular tissue protein Li 215
thioredoxin domain containing 2 (spermatozoa)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098529.2NP_001091999.1  thioredoxin domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001091999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, resulting in a longer open reading frame through the use of an upstream start codon, compared to variant 1. The predicted protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AC006238, AF080095, AK097656, BC050132, DB032859
    Consensus CDS
    CCDS42414.1
    UniProtKB/Swiss-Prot
    Q86VQ3
    UniProtKB/TrEMBL
    A0A140VJY8
    Related
    ENSP00000304908.6, ENST00000306084.6
    Conserved Domains (1) summary
    cd02947
    Location:457550
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
  2. NM_032243.6NP_115619.4  thioredoxin domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_115619.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant protein (isoform 1) and represents the variant originally described in PMID: 11399755.
    Source sequence(s)
    AC006238, AF080095, BC050132
    Consensus CDS
    CCDS11846.1
    UniProtKB/Swiss-Prot
    Q86VQ3
    Related
    ENSP00000350419.4, ENST00000357775.5
    Conserved Domains (1) summary
    cd02947
    Location:390483
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    9885973..9889275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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