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CIAO2A cytosolic iron-sulfur assembly component 2A [ Homo sapiens (human) ]

Gene ID: 84191, updated on 17-Jun-2019

Summary

Official Symbol
CIAO2Aprovided by HGNC
Official Full Name
cytosolic iron-sulfur assembly component 2Aprovided by HGNC
Primary source
HGNC:HGNC:26235
See related
Ensembl:ENSG00000166797 MIM:618382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIA2A; FAM96A
Expression
Ubiquitous expression in liver (RPKM 13.5), duodenum (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See CIAO2A in Genome Data Viewer
Location:
15q22.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64072559..64094008, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64364761..64386207, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene death associated protein kinase 2 Neighboring gene sorting nexin 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22875

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation by [4Fe-4S] cluster transfer IEA
Inferred from Electronic Annotation
more info
 
protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CIA complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytosolic iron-sulfur assembly component 2A
Names
MIP18 family protein FAM96A
family with sequence similarity 96 member A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014812.2NP_001014812.1  cytosolic iron-sulfur assembly component 2A isoform b precursor

    See identical proteins and their annotated locations for NP_001014812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AA809560, BC008865, BM706342, BQ269528, CN421575
    Consensus CDS
    CCDS45278.1
    UniProtKB/Swiss-Prot
    Q9H5X1
    Related
    ENSP00000369644.3, ENST00000380290.7
    Conserved Domains (1) summary
    cl00941
    Location:3996
    DUF59; Domain of unknown function DUF59
  2. NM_001289108.1NP_001276037.1  cytosolic iron-sulfur assembly component 2A isoform b precursor

    See identical proteins and their annotated locations for NP_001276037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal coding exon that causes a frame-shift and differs at the 3' end compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AA809560, AC021541, AK304202, BC008865, BM706342, CD722050, CN421575
    Consensus CDS
    CCDS45278.1
    UniProtKB/Swiss-Prot
    Q9H5X1
    Related
    ENSP00000454079.1, ENST00000557835.5
    Conserved Domains (1) summary
    cl00941
    Location:3996
    DUF59; Domain of unknown function DUF59
  3. NM_032231.6NP_115607.1  cytosolic iron-sulfur assembly component 2A isoform a precursor

    See identical proteins and their annotated locations for NP_115607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC008865, CN421575
    Consensus CDS
    CCDS10189.1
    UniProtKB/Swiss-Prot
    Q9H5X1
    Related
    ENSP00000300030.3, ENST00000300030.8
    Conserved Domains (1) summary
    cl00941
    Location:39156
    DUF59; Domain of unknown function DUF59

RNA

  1. NR_110310.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a novel exon in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA809560, BC008865, BM706342, CN421575, DC415981

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64072559..64094008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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