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CHD6 chromodomain helicase DNA binding protein 6 [ Homo sapiens (human) ]

Gene ID: 84181, updated on 12-Oct-2019

Summary

Official Symbol
CHD6provided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 6provided by HGNC
Primary source
HGNC:HGNC:19057
See related
Ensembl:ENSG00000124177 MIM:616114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHD5; RIGB; CHD-6
Summary
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 7.0), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See CHD6 in Genome Data Viewer
Location:
20q12
Exon count:
43
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (41402083..41618377, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (40030741..40247133, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene lipin 3 Neighboring gene zinc finger MYM-type containing 1 pseudogene Neighboring gene elastin microfibril interfacer 3 Neighboring gene ribosomal protein L12 pseudogene 11 Neighboring gene NFE2L2 motif-containing MPRA enhancer 172 Neighboring gene RNA, U6 small nuclear 1018, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription cofactor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chromodomain-helicase-DNA-binding protein 6
Names
ATP-dependent helicase CHD6
helicase C-terminal domain- and SNF2 N-terminal domain-containing protein
radiation-induced gene B protein
NP_115597.3
XP_005260630.1
XP_005260633.1
XP_011527382.1
XP_011527384.1
XP_016883588.1
XP_016883589.1
XP_016883590.1
XP_016883591.1
XP_016883592.1
XP_016883593.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050686.1 RefSeqGene

    Range
    5001..221394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032221.5NP_115597.3  chromodomain-helicase-DNA-binding protein 6

    See identical proteins and their annotated locations for NP_115597.3

    Status: REVIEWED

    Source sequence(s)
    AL031667, AL031669, AL121674
    Consensus CDS
    CCDS13317.1
    UniProtKB/Swiss-Prot
    Q8TD26
    Related
    ENSP00000362330.3, ENST00000373233.8
    Conserved Domains (5) summary
    cd00046
    Location:480629
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:464751
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:783897
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:376429
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl02688
    Location:24022437
    BRK; BRK domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    41402083..41618377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260573.2XP_005260630.1  chromodomain-helicase-DNA-binding protein 6 isoform X3

    Conserved Domains (5) summary
    cd00046
    Location:458607
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:442729
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:761875
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:354407
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl02688
    Location:23802415
    BRK; BRK domain
  2. XM_017028100.1XP_016883589.1  chromodomain-helicase-DNA-binding protein 6 isoform X3

    Conserved Domains (5) summary
    cd00046
    Location:458607
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:442729
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:761875
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:354407
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl02688
    Location:23802415
    BRK; BRK domain
  3. XM_011529080.2XP_011527382.1  chromodomain-helicase-DNA-binding protein 6 isoform X2

    Conserved Domains (5) summary
    cd00046
    Location:478627
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:462749
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:781895
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:374427
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl02688
    Location:24002435
    BRK; BRK domain
  4. XM_017028101.1XP_016883590.1  chromodomain-helicase-DNA-binding protein 6 isoform X4

  5. XM_017028099.2XP_016883588.1  chromodomain-helicase-DNA-binding protein 6 isoform X1

  6. XM_017028103.1XP_016883592.1  chromodomain-helicase-DNA-binding protein 6 isoform X6

  7. XM_011529082.2XP_011527384.1  chromodomain-helicase-DNA-binding protein 6 isoform X8

    Conserved Domains (2) summary
    smart00592
    Location:17251760
    BRK; domain in transcription and CHROMO domain helicases
    pfam00271
    Location:106220
    Helicase_C; Helicase conserved C-terminal domain
  8. XM_005260576.4XP_005260633.1  chromodomain-helicase-DNA-binding protein 6 isoform X9

    Conserved Domains (1) summary
    cl02688
    Location:10511086
    BRK; BRK domain
  9. XM_017028102.1XP_016883591.1  chromodomain-helicase-DNA-binding protein 6 isoform X5

  10. XM_017028104.1XP_016883593.1  chromodomain-helicase-DNA-binding protein 6 isoform X7

RNA

  1. XR_001754421.2 RNA Sequence

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