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PPC1 phosphoenolpyruvate carboxylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841765, updated on 23-Jul-2026
Official Symbol
PPC1
Official Full Name
phosphoenolpyruvate carboxylase 1
Primary source
TAIR:AT1G53310
Locus tag
AT1G53310
See related
Araport:AT1G53310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPEPC1; ATPPC1; F12M16.21; F12M16_21; PEP(PHOSPHOENOLPYRUVATE) CARBOXYLASE 1; PEPC1; phosphoenolpyruvate carboxylase 1
Summary
Encodes one of four Arabidopsis phosphoenolpyruvate carboxylase proteins.
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See PPC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (19883935..19888413, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Galactosyltransferase family protein Neighboring gene tetratricopetide-repeat thioredoxin-like 1 Neighboring gene tubby like protein 7 Neighboring gene F-box associated ubiquitination effector family protein

Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana. Gregory AL, et al. Biochem J, 2009 Apr 28. PMID 19228119, Free PMC Article
  2. Phosphoenolpyruvate Carboxylase in Arabidopsis Leaves Plays a Crucial Role in Carbon and Nitrogen Metabolism. Shi J, et al. Plant Physiol, 2015 Mar. PMID 25588735, Free PMC Article
  3. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
  4. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
  5. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PEPC in leaves plays a crucial role in modulating the balance of carbon and nitrogen metabolism in Arabidopsis.
    Title: Phosphoenolpyruvate Carboxylase in Arabidopsis Leaves Plays a Crucial Role in Carbon and Nitrogen Metabolism.
  2. Phosphorylation activated AtPPC1 at pH 7.3 by lowering its Km(PEP) and its sensitivity to inhibition by L-malate and L-aspartate, while enhancing activation by glucose 6-phosphate
    Title: In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_001036101.2
NM_001036102.3
NM_104209.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphoenolpyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoenolpyruvate carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoenolpyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbon fixation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein tetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
Preferred Names
phosphoenolpyruvate carboxylase 1
NP_001031178.1
  • phosphoenolpyruvate carboxylase 1 (PPC1); FUNCTIONS IN: protein binding, phosphoenolpyruvate carboxylase activity; INVOLVED IN: response to salt stress, tricarboxylic acid cycle; LOCATED IN: cytosol, apoplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 3 (TAIR:AT3G14940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001031179.1
  • phosphoenolpyruvate carboxylase 1 (PPC1); FUNCTIONS IN: protein binding, phosphoenolpyruvate carboxylase activity; INVOLVED IN: response to salt stress, tricarboxylic acid cycle; LOCATED IN: cytosol, apoplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 3 (TAIR:AT3G14940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_175738.1
  • phosphoenolpyruvate carboxylase 1 (PPC1); FUNCTIONS IN: protein binding, phosphoenolpyruvate carboxylase activity; INVOLVED IN: response to salt stress, tricarboxylic acid cycle; LOCATED IN: cytosol, apoplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 3 (TAIR:AT3G14940.1); Has 6864 Blast hits to 6795 proteins in 1908 species: Archae - 27; Bacteria - 2661; Metazoa - 3; Fungi - 0; Plants - 1763; Viruses - 0; Other Eukaryotes - 2410 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    19883935..19888413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001036101.2 → NP_001031178.1  phosphoenolpyruvate carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031178.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q546E4, Q9MAH0
    UniProtKB/TrEMBL
    B9DGT6
    Conserved Domains (1) summary
    pfam00311
    Location:164 → 967
    PEPcase; Phosphoenolpyruvate carboxylase

  2. NM_104209.3 → NP_175738.1  phosphoenolpyruvate carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q546E4, Q9MAH0
    UniProtKB/TrEMBL
    B9DGT6
    Conserved Domains (1) summary
    pfam00311
    Location:164 → 967
    PEPcase; Phosphoenolpyruvate carboxylase

  3. NM_001036102.3 → NP_001031179.1  phosphoenolpyruvate carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031179.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q546E4, Q9MAH0
    UniProtKB/TrEMBL
    B9DGT6
    Conserved Domains (1) summary
    pfam00311
    Location:164 → 967
    PEPcase; Phosphoenolpyruvate carboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MAH0.1

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