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MYH16 myosin heavy chain 16 [ Homo sapiens (human) ]

Gene ID: 84176, updated on 25-Nov-2025
Official Symbol
MYH16provided by HGNC
Official Full Name
myosin heavy chain 16provided by HGNC
Primary source
HGNC:HGNC:31038
See related
MIM:608580; AllianceGenome:HGNC:31038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYH5; MHC20; MYH16P
Summary
The protein coding status of the MYH16 gene is uncertain. In nonhuman primates, this gene encodes a sarcomeric myosin heavy chain expressed in masticatory muscles, but has been hypothesized to be inactivated in humans. Stedman et al. (2004) [PubMed 15042088] suggest that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man. However, there is peptide support suggesting that a shorter protein containing only a myosin tail domain is expressed in human. [provided by RefSeq, Jul 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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See MYH16 in Genome Data Viewer
Location:
7q22.1
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99238829..99311128)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100477712..100550022)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (98836452..98908751)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98631759-98632259 Neighboring gene Sharpr-MPRA regulatory region 1794 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98695995-98696849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98696850-98697703 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:98700145-98701344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98706490-98706992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18402 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:98749275-98749496 Neighboring gene karyopherin subunit alpha 7 Neighboring gene Sharpr-MPRA regulatory region 10979 Neighboring gene Sharpr-MPRA regulatory region 10425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98848211-98848712 Neighboring gene uncharacterized LOC105375421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18403 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98923087-98923646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98955605-98956105 Neighboring gene actin related protein 2/3 complex subunit 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98957299-98957799 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:98962524-98962729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98966657-98967570 Neighboring gene Sharpr-MPRA regulatory region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98970933-98971433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98991459-98992130 Neighboring gene actin related protein 2/3 complex subunit 1B Neighboring gene PDGFA associated protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration. Zhang L, et al. J Biochem Mol Toxicol, 2023 Dec. PMID 37589445
  2. Of muscle-bound crania and human brain evolution: the story behind the MYH16 headlines. McCollum MA, et al. J Hum Evol, 2006 Feb. PMID 16376411
  3. Comparative analyses reveal a complex history of molecular evolution for human MYH16. Perry GH, et al. Mol Biol Evol, 2005 Mar. PMID 15470226
  4. Myosin gene mutation correlates with anatomical changes in the human lineage. Stedman HH, et al. Nature, 2004 Mar 25. PMID 15042088
  5. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. Desjardins PR, et al. Mol Biol Evol, 2002 Apr. PMID 11919279

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
    Title: MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
  2. first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record
    Title: Myosin gene mutation correlates with anatomical changes in the human lineage.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22037

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative uncharacterized protein MYH16
Names
myosin heavy chain 16 (pseudogene)
myosin heavy polypeptide 5
myosin, heavy polypeptide 16
sarcomeric myosin

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431356.1 → NP_001418285.1  putative uncharacterized protein MYH16

    Status: REVIEWED

    Source sequence(s)
    AC004834
    UniProtKB/Swiss-Prot
    Q9H6N6

RNA

  1. NR_002147.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004834, AC005163, AC112711

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99238829..99311128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100477712..100550022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6N6.2 GenPept UniProtKB/Swiss-Prot:Q9H6N6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials