MYH16 myosin heavy chain 16 pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYH16provided by HGNC
Official Full Name: myosin heavy chain 16 pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:31038
See related: Ensembl:ENSG00000002079 MIM:608580; AllianceGenome:HGNC:31038
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MYH5; MHC20; MYH16P
Summary: The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7q22.1

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99238829..99311128)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (100477712..100550022)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (98836452..98908751)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record
Title: Myosin gene mutation correlates with anatomical changes in the human lineage.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S1463 (e-PCR)
- UniSTS:69713

RH70329 (e-PCR)
- UniSTS:73839

D7S1553 (e-PCR)
- UniSTS:20630

GDB:1234280 (e-PCR)
- UniSTS:58843

Other Names

myosin heavy polypeptide 5
myosin, heavy chain 16
myosin, heavy polypeptide 16
sarcomeric myosin

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
part_of myosin complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.