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SLA2 Src like adaptor 2 [ Homo sapiens (human) ]

Gene ID: 84174, updated on 15-Jun-2019

Summary

Official Symbol
SLA2provided by HGNC
Official Full Name
Src like adaptor 2provided by HGNC
Primary source
HGNC:HGNC:17329
See related
Ensembl:ENSG00000101082 MIM:606577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARS; SLAP2; SLAP-2; C20orf156
Summary
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 4.0), bone marrow (RPKM 3.6) and 17 other tissues See more
Orthologs

Genomic context

See SLA2 in Genome Data Viewer
Location:
20q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (36612519..36646216, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35240922..35274619, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene TGFB induced factor homeobox 2 Neighboring gene uncharacterized LOC107985397 Neighboring gene RAB5 interacting factor Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 2 Neighboring gene NDRG family member 3 Neighboring gene DSN1 component of MIS12 kinetochore complex

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21992, MGC49845

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3/SH2 adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
src-like-adapter 2
Names
Src-like adapter protein-2
modulator of antigen receptor signaling

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031823.2 RefSeqGene

    Range
    5001..38698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032214.4NP_115590.1  src-like-adapter 2 isoform a

    See identical proteins and their annotated locations for NP_115590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL050318, BC042041, BF510664, DA983348
    Consensus CDS
    CCDS13282.1
    UniProtKB/Swiss-Prot
    Q9H6Q3
    Related
    ENSP00000262866.4, ENST00000262866.9
    Conserved Domains (2) summary
    cd10344
    Location:83186
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12011
    Location:3690
    SH3_SLAP2; Src homology 3 domain of Src-Like Adaptor Protein 2
  2. NM_175077.3NP_778252.1  src-like-adapter 2 isoform b

    See identical proteins and their annotated locations for NP_778252.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as SLAP-2-v) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF290986, AL050318, BC042041, BF510664, BQ052468, DA983348
    Consensus CDS
    CCDS13283.1
    UniProtKB/Swiss-Prot
    Q9H6Q3
    Related
    ENSP00000353890.2, ENST00000360672.2
    Conserved Domains (2) summary
    cd12011
    Location:3690
    SH3_SLAP2; Src homology 3 domain of Src-Like Adaptor Protein 2
    cl15255
    Location:83178
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36612318..36646207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028098.1XP_016883587.1  src-like-adapter 2 isoform X1

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