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LOXL4 lysyl oxidase like 4 [ Homo sapiens (human) ]

Gene ID: 84171, updated on 1-Jun-2020

Summary

Official Symbol
LOXL4provided by HGNC
Official Full Name
lysyl oxidase like 4provided by HGNC
Primary source
HGNC:HGNC:17171
See related
Ensembl:ENSG00000138131 MIM:607318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOXC
Summary
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues See more
Orthologs

Genomic context

See LOXL4 in Genome Data Viewer
Location:
10q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (98247690..98268221, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (100007443..100028007, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 340 Neighboring gene cartilage acidic protein 1 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene uncharacterized LOC105378449 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 2 Neighboring gene microRNA 1287

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-lysine 6-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysyl oxidase homolog 4
Names
lysyl oxidase related C
lysyl oxidase-like 4 pseudogene
lysyl oxidase-like protein 4
lysyl oxidase-related protein C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032211.7NP_115587.6  lysyl oxidase homolog 4 precursor

    See identical proteins and their annotated locations for NP_115587.6

    Status: REVIEWED

    Source sequence(s)
    AK172781, BC013153, W44920
    Consensus CDS
    CCDS7473.1
    UniProtKB/Swiss-Prot
    Q96JB6
    Related
    ENSP00000260702.3, ENST00000260702.4
    Conserved Domains (3) summary
    smart00202
    Location:32132
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:41132
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01186
    Location:533728
    Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    98247690..98268221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270216.2XP_005270273.1  lysyl oxidase homolog 4 isoform X1

    See identical proteins and their annotated locations for XP_005270273.1

    Conserved Domains (2) summary
    smart00202
    Location:32132
    SR; Scavenger receptor Cys-rich
    pfam01186
    Location:534733
    Lysyl_oxidase; Lysyl oxidase
  2. XM_006718020.1XP_006718083.1  lysyl oxidase homolog 4 isoform X1

    See identical proteins and their annotated locations for XP_006718083.1

    Conserved Domains (2) summary
    smart00202
    Location:32132
    SR; Scavenger receptor Cys-rich
    pfam01186
    Location:534733
    Lysyl_oxidase; Lysyl oxidase
  3. XM_024448232.1XP_024304000.1  lysyl oxidase homolog 4 isoform X1

    Conserved Domains (2) summary
    smart00202
    Location:32132
    SR; Scavenger receptor Cys-rich
    pfam01186
    Location:534733
    Lysyl_oxidase; Lysyl oxidase
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