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STX7 syntaxin 7 [ Homo sapiens (human) ]

Gene ID: 8417, updated on 9-Dec-2018

Summary

Official Symbol
STX7provided by HGNC
Official Full Name
syntaxin 7provided by HGNC
Primary source
HGNC:HGNC:11442
See related
Ensembl:ENSG00000079950 MIM:603217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues See more
Orthologs

Genomic context

See STX7 in Genome Data Viewer
Location:
6q23.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (132457524..132513472, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132778663..132834337, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 36 Neighboring gene monooxygenase DBH like 1 Neighboring gene ribosomal protein L21 pseudogene 66 Neighboring gene trace amine associated receptor 9 (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle assembly IDA
Inferred from Direct Assay
more info
PubMed 
organelle localization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane HDA PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tertiary granule IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050740.1 RefSeqGene

    Range
    5275..56999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326578.1NP_001313507.1  syntaxin-7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    O15400
    Conserved Domains (2) summary
    cd15875
    Location:168227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18119
    Syntaxin_2; Syntaxin-like protein
  2. NM_001326579.1NP_001313508.1  syntaxin-7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    O15400
    Conserved Domains (2) summary
    cd15875
    Location:168227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18119
    Syntaxin_2; Syntaxin-like protein
  3. NM_001326580.1NP_001313509.1  syntaxin-7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL357034, AL589691
    Consensus CDS
    CCDS87441.1
    UniProtKB/Swiss-Prot
    O15400
    Related
    ENSP00000356914.4, ENST00000367937.4
    Conserved Domains (2) summary
    cd00179
    Location:9148
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15875
    Location:168227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
  4. NM_003569.3NP_003560.2  syntaxin-7 isoform a

    See identical proteins and their annotated locations for NP_003560.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AJ420529, AL357034, AW500305, BC011975, BF064142, DA242979, U77942
    Consensus CDS
    CCDS5153.1
    UniProtKB/Swiss-Prot
    O15400
    Related
    ENSP00000356918.1, ENST00000367941.6
    Conserved Domains (2) summary
    cd15875
    Location:168227
    SNARE_syntaxin7; SNARE motif of syntaxin 7
    pfam14523
    Location:18119
    Syntaxin_2; Syntaxin-like protein

RNA

  1. NR_137169.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL357034, AL589691

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    132457524..132513472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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