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NLRC5 NLR family CARD domain containing 5 [ Homo sapiens (human) ]

Gene ID: 84166, updated on 25-Nov-2021

Summary

Official Symbol
NLRC5provided by HGNC
Official Full Name
NLR family CARD domain containing 5provided by HGNC
Primary source
HGNC:HGNC:29933
See related
Ensembl:ENSG00000140853 MIM:613537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOD4; NOD27; CLR16.1
Summary
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Expression
Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues See more
Orthologs
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Genomic context

See NLRC5 in Genome Data Viewer
Location:
16q13
Exon count:
57
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56989557..57083520)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57023469..57117432)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13851 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1 Neighboring gene Sharpr-MPRA regulatory region 2679 Neighboring gene cholesteryl ester transfer protein Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene cilia and flagella associated protein 69 pseudogene Neighboring gene copine 2 Neighboring gene uncharacterized LOC105371289 Neighboring gene Sharpr-MPRA regulatory region 3054

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
GeneReviews: Not available
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
GeneReviews: Not available
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NLR family, CARD domain containing 5 (NLRC5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21709, FLJ39711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class I biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MHC class I biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein NLRC5
Names
NOD-like receptor C5
caterpiller protein 16.1
nucleotide-binding oligomerization domain protein 4
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5
nucleotide-binding oligomerization domains 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030337.3 RefSeqGene

    Range
    32590..99040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330552.2NP_001317481.1  protein NLRC5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AA722775, AC009090, AC023825
    Consensus CDS
    CCDS81985.1
    UniProtKB/Swiss-Prot
    Q86WI3
    Related
    ENSP00000441727.1, ENST00000539144.5
    Conserved Domains (6) summary
    sd00033
    Location:14951516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14361466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14931793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_001384950.1NP_001371879.1  protein NLRC5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:15241545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14651495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15221822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. NM_001384951.1NP_001371880.1  protein NLRC5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14951516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14361466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14931793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. NM_001384952.1NP_001371881.1  protein NLRC5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:15231544
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14641494
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15211821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  5. NM_001384953.1NP_001371882.1  protein NLRC5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:15231544
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14641494
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15211821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  6. NM_001384954.1NP_001371883.1  protein NLRC5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14961517
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14371467
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14941794
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  7. NM_001384955.1NP_001371884.1  protein NLRC5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14951516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14361466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14931793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  8. NM_001384956.1NP_001371885.1  protein NLRC5 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14951516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14361466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14931793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  9. NM_001384957.1NP_001371886.1  protein NLRC5 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14941515
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14351465
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14921792
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  10. NM_001384958.1NP_001371887.1  protein NLRC5 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (7) summary
    sd00033
    Location:14661487
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14071437
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:14641764
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  11. NM_001384959.1NP_001371888.1  protein NLRC5 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (7) summary
    sd00033
    Location:14651486
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14061436
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:14631763
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  12. NM_001384960.1NP_001371889.1  protein NLRC5 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:14931520
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:13831405
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:14471735
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  13. NM_001384961.1NP_001371890.1  protein NLRC5 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 15, encodes isoform 11.
    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  14. NM_001384962.1NP_001371891.1  protein NLRC5 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 14, encodes isoform 11.
    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  15. NM_001384963.1NP_001371892.1  protein NLRC5 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.
    Source sequence(s)
    AC023825
    Related
    ENSP00000442906.1, ENST00000538805.5
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  16. NM_001384964.1NP_001371893.1  protein NLRC5 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.
    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  17. NM_001384965.1NP_001371894.1  protein NLRC5 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:688715
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:8191040
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  18. NM_001384966.1NP_001371895.1  protein NLRC5 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  19. NM_001384967.1NP_001371896.1  protein NLRC5 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  20. NM_001384968.1NP_001371897.1  protein NLRC5 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  21. NM_001384969.1NP_001371898.1  protein NLRC5 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  22. NM_001384970.1NP_001371899.1  protein NLRC5 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  23. NM_001384971.1NP_001371900.1  protein NLRC5 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  24. NM_001384972.1NP_001371901.1  protein NLRC5 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (5) summary
    sd00033
    Location:659686
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:205326
    NACHT; NACHT domain
    pfam17776
    Location:457571
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:633989
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  25. NM_001384973.1NP_001371902.1  protein NLRC5 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (6) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:7451069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  26. NM_032206.5NP_115582.4  protein NLRC5 isoform 1

    See identical proteins and their annotated locations for NP_115582.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC009090, AC023825
    Consensus CDS
    CCDS10773.1
    UniProtKB/Swiss-Prot
    Q86WI3
    UniProtKB/TrEMBL
    Q6MZW3, Q9H6Y0
    Related
    ENSP00000262510.6, ENST00000262510.10
    Conserved Domains (6) summary
    sd00033
    Location:15241545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14651495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15221822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

  1. NR_169512.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  2. NR_169513.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  3. NR_169514.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023825
  4. NR_169515.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  5. NR_169516.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  6. NR_169517.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  7. NR_169518.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  8. NR_169519.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
  9. NR_169520.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    56989557..57083520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721298.2XP_006721361.1  protein NLRC5 isoform X5

    Conserved Domains (7) summary
    smart00382
    Location:221365
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:731936
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:14921792
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:14941515
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14351465
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam13855
    Location:15501616
    LRR_8; Leucine rich repeat
  2. XM_005256196.2XP_005256253.1  protein NLRC5 isoform X3

    Conserved Domains (7) summary
    smart00382
    Location:221365
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:703908
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:14941794
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:14961517
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14371467
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam13855
    Location:15521618
    LRR_8; Leucine rich repeat
  3. XM_006721300.2XP_006721363.1  protein NLRC5 isoform X10

    Conserved Domains (5) summary
    smart00382
    Location:221365
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:731936
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
  4. XM_017023771.2XP_016879260.1  protein NLRC5 isoform X12

    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  5. XM_017023770.1XP_016879259.1  protein NLRC5 isoform X8

  6. XM_005256201.3XP_005256258.1  protein NLRC5 isoform X9

    Conserved Domains (5) summary
    sd00033
    Location:716743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:6901069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  7. XM_005256194.4XP_005256251.1  protein NLRC5 isoform X1

    See identical proteins and their annotated locations for XP_005256251.1

    UniProtKB/Swiss-Prot
    Q86WI3
    Conserved Domains (6) summary
    sd00033
    Location:15241545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14651495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15221822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  8. XM_011523373.2XP_011521675.1  protein NLRC5 isoform X1

    See identical proteins and their annotated locations for XP_011521675.1

    UniProtKB/Swiss-Prot
    Q86WI3
    Conserved Domains (6) summary
    sd00033
    Location:15241545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:14651495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222383
    NACHT; NACHT domain
    pfam17776
    Location:514628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:195
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:15221822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  9. XM_011523376.2XP_011521678.1  protein NLRC5 isoform X13

    Conserved Domains (5) summary
    COG4886
    Location:19224
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:8101110
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:812833
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:753783
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam13855
    Location:868934
    LRR_8; Leucine rich repeat

RNA

  1. XR_429734.2 RNA Sequence

    Related
    ENST00000545081.5
  2. XR_001751997.1 RNA Sequence

  3. XR_001751998.1 RNA Sequence

  4. XR_001751999.1 RNA Sequence

  5. XR_001752000.1 RNA Sequence

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