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ASCC2 activating signal cointegrator 1 complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 84164, updated on 26-Oct-2022

Summary

Official Symbol
ASCC2provided by HGNC
Official Full Name
activating signal cointegrator 1 complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:24103
See related
Ensembl:ENSG00000100325 MIM:614216; AllianceGenome:HGNC:24103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p100; ASC1p100
Summary
Predicted to enable ubiquitin binding activity. Involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of activating signal cointegrator 1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 13.0), testis (RPKM 12.7) and 25 other tissues See more
Orthologs
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Genomic context

See ASCC2 in Genome Data Viewer
Location:
22q12.2
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29788611..29838274, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30251982..30301644, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30184600..30234263, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene calcium binding protein 7 Neighboring gene zinc finger matrin-type 5 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X Neighboring gene Sharpr-MPRA regulatory region 2042 Neighboring gene RNA, U6 small nuclear 331, pseudogene Neighboring gene myotubularin related protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
activating signal cointegrator 1 complex subunit 2
Names
ASC-1 complex subunit P100
trip4 complex subunit p100

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242906.2NP_001229835.1  activating signal cointegrator 1 complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Consensus CDS
    CCDS56226.1
    UniProtKB/Swiss-Prot
    Q9H1I8
    Related
    ENSP00000437570.1, ENST00000542393.5
    Conserved Domains (1) summary
    cd14364
    Location:393432
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  2. NM_001369920.1NP_001356849.1  activating signal cointegrator 1 complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  3. NM_001369921.1NP_001356850.1  activating signal cointegrator 1 complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Consensus CDS
    CCDS13869.1
    UniProtKB/Swiss-Prot
    Q9H9D6
    UniProtKB/TrEMBL
    A0A024R1F9
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  4. NM_001369922.1NP_001356851.1  activating signal cointegrator 1 complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Consensus CDS
    CCDS13869.1
    UniProtKB/Swiss-Prot
    Q9H9D6
    UniProtKB/TrEMBL
    A0A024R1F9
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  5. NM_001369923.1NP_001356852.1  activating signal cointegrator 1 complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Consensus CDS
    CCDS13869.1
    UniProtKB/Swiss-Prot
    Q9H9D6
    UniProtKB/TrEMBL
    A0A024R1F9
    Related
    ENSP00000380877.2, ENST00000397771.6
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  6. NM_001369924.1NP_001356853.1  activating signal cointegrator 1 complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  7. NM_001369925.1NP_001356854.1  activating signal cointegrator 1 complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  8. NM_001369926.1NP_001356855.1  activating signal cointegrator 1 complex subunit 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  9. NM_001369927.1NP_001356856.1  activating signal cointegrator 1 complex subunit 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  10. NM_001369928.1NP_001356857.1  activating signal cointegrator 1 complex subunit 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  11. NM_001369929.1NP_001356858.1  activating signal cointegrator 1 complex subunit 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  12. NM_001369930.1NP_001356859.1  activating signal cointegrator 1 complex subunit 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:391430
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  13. NM_001369931.1NP_001356860.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  14. NM_001369932.1NP_001356861.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  15. NM_001369933.1NP_001356862.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  16. NM_001369934.1NP_001356863.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  17. NM_001369935.1NP_001356864.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  18. NM_001369936.1NP_001356865.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  19. NM_001369937.1NP_001356866.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  20. NM_001369938.1NP_001356867.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  21. NM_001369939.1NP_001356868.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  22. NM_001369940.1NP_001356869.1  activating signal cointegrator 1 complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    UniProtKB/TrEMBL
    A0A024R1E1
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  23. NM_001369941.1NP_001356870.1  activating signal cointegrator 1 complex subunit 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  24. NM_001369942.1NP_001356871.1  activating signal cointegrator 1 complex subunit 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:291330
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  25. NM_001369943.1NP_001356872.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  26. NM_001369944.1NP_001356873.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  27. NM_001369945.1NP_001356874.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  28. NM_001369946.1NP_001356875.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  29. NM_001369947.1NP_001356876.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  30. NM_001369948.1NP_001356877.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  31. NM_001369949.1NP_001356878.1  activating signal cointegrator 1 complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  32. NM_001369950.1NP_001356879.1  activating signal cointegrator 1 complex subunit 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC004882, Z82171
    Conserved Domains (1) summary
    cd14364
    Location:233272
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  33. NM_032204.5NP_115580.2  activating signal cointegrator 1 complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_115580.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC025368, BP201867
    Consensus CDS
    CCDS13869.1
    UniProtKB/Swiss-Prot
    Q9H1I8, Q9H9D6
    UniProtKB/TrEMBL
    A0A024R1F9
    Related
    ENSP00000305502.3, ENST00000307790.8
    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    29788611..29838274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441548.1XP_047297504.1  activating signal cointegrator 1 complex subunit 2 isoform X15

  2. XM_011530455.3XP_011528757.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    See identical proteins and their annotated locations for XP_011528757.1

    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  3. XM_047441545.1XP_047297501.1  activating signal cointegrator 1 complex subunit 2 isoform X11

  4. XM_047441541.1XP_047297497.1  activating signal cointegrator 1 complex subunit 2 isoform X9

  5. XM_011530454.3XP_011528756.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    See identical proteins and their annotated locations for XP_011528756.1

    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  6. XM_011530453.3XP_011528755.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    See identical proteins and their annotated locations for XP_011528755.1

    Conserved Domains (1) summary
    cd14364
    Location:355394
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  7. XM_011530448.3XP_011528750.1  activating signal cointegrator 1 complex subunit 2 isoform X12

    See identical proteins and their annotated locations for XP_011528750.1

    Conserved Domains (1) summary
    cd14364
    Location:416455
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  8. XM_047441543.1XP_047297499.1  activating signal cointegrator 1 complex subunit 2 isoform X11

  9. XM_011530442.4XP_011528744.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    See identical proteins and their annotated locations for XP_011528744.1

    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  10. XM_047441544.1XP_047297500.1  activating signal cointegrator 1 complex subunit 2 isoform X11

  11. XM_011530443.3XP_011528745.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    See identical proteins and their annotated locations for XP_011528745.1

    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  12. XM_047441547.1XP_047297503.1  activating signal cointegrator 1 complex subunit 2 isoform X13

  13. XM_047441546.1XP_047297502.1  activating signal cointegrator 1 complex subunit 2 isoform X11

  14. XM_011530445.3XP_011528747.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    See identical proteins and their annotated locations for XP_011528747.1

    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  15. XM_047441540.1XP_047297496.1  activating signal cointegrator 1 complex subunit 2 isoform X8

    UniProtKB/Swiss-Prot
    Q9H9D6
    UniProtKB/TrEMBL
    A0A024R1F9
  16. XM_011530444.3XP_011528746.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    See identical proteins and their annotated locations for XP_011528746.1

    Conserved Domains (1) summary
    cd14364
    Location:469508
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  17. XM_047441539.1XP_047297495.1  activating signal cointegrator 1 complex subunit 2 isoform X6

  18. XM_047441542.1XP_047297498.1  activating signal cointegrator 1 complex subunit 2 isoform X10

  19. XM_024452290.2XP_024308058.1  activating signal cointegrator 1 complex subunit 2 isoform X5

    Conserved Domains (1) summary
    cd14364
    Location:470509
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  20. XM_024452288.2XP_024308056.1  activating signal cointegrator 1 complex subunit 2 isoform X3

    Conserved Domains (1) summary
    cd14364
    Location:498537
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  21. XM_024452287.2XP_024308055.1  activating signal cointegrator 1 complex subunit 2 isoform X1

    Conserved Domains (1) summary
    cd14364
    Location:523562
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  22. XM_024452291.2XP_024308059.1  activating signal cointegrator 1 complex subunit 2 isoform X7

    Conserved Domains (1) summary
    cd14364
    Location:470509
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  23. XM_024452289.2XP_024308057.1  activating signal cointegrator 1 complex subunit 2 isoform X4

    Conserved Domains (1) summary
    cd14364
    Location:498537
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
  24. XM_047441538.1XP_047297494.1  activating signal cointegrator 1 complex subunit 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    30251982..30301644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)