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KAT8 lysine acetyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 84148, updated on 17-Jun-2019

Summary

Official Symbol
KAT8provided by HGNC
Official Full Name
lysine acetyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:17933
See related
Ensembl:ENSG00000103510 MIM:609912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOF; hMOF; MYST1; ZC2HC8
Summary
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in ovary (RPKM 17.1), testis (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See KAT8 in Genome Data Viewer
Location:
16p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31117664..31131393)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31128985..31142714)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vitamin K epoxide reductase complex subunit 1 Neighboring gene branched chain keto acid dehydrogenase kinase Neighboring gene serine protease 8 Neighboring gene serine protease 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14040

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity (H4-K16 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity (H4-K16 specific) IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone acetyltransferase activity (H4-K5 specific) IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone acetyltransferase activity (H4-K8 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K16 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MSL complex IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT8
Names
K(lysine) acetyltransferase 8
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
MYST histone acetyltransferase 1
MYST-1
histone acetyltransferase MYST1
ortholog of Drosophila males absent on the first (MOF)
probable histone acetyltransferase MYST1
NP_115564.2
NP_892003.2
XP_011544272.1
XP_011544273.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032188.3NP_115564.2  histone acetyltransferase KAT8 isoform 1

    See identical proteins and their annotated locations for NP_115564.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AA682878, AK291106, BP342476, CD364543
    Consensus CDS
    CCDS10706.1
    UniProtKB/Swiss-Prot
    Q9H7Z6
    Related
    ENSP00000219797.3, ENST00000219797.9
    Conserved Domains (3) summary
    PLN00104
    Location:15449
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:55111
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:160427
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  2. NM_182958.3NP_892003.2  histone acetyltransferase KAT8 isoform 2

    See identical proteins and their annotated locations for NP_892003.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AC009088, AC135050
    Consensus CDS
    CCDS45468.1
    UniProtKB/Swiss-Prot
    Q9H7Z6
    Related
    ENSP00000406037.2, ENST00000448516.6
    Conserved Domains (3) summary
    PLN00104
    Location:15429
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:55111
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:160427
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31117664..31131393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545971.1XP_011544273.1  histone acetyltransferase KAT8 isoform X1

    See identical proteins and their annotated locations for XP_011544273.1

    Conserved Domains (1) summary
    cl27485
    Location:6291
    MOZ_SAS; MOZ/SAS family
  2. XM_011545970.1XP_011544272.1  histone acetyltransferase KAT8 isoform X1

    See identical proteins and their annotated locations for XP_011544272.1

    Conserved Domains (1) summary
    cl27485
    Location:6291
    MOZ_SAS; MOZ/SAS family
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