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ZNF644 zinc finger protein 644 [ Homo sapiens (human) ]

Gene ID: 84146, updated on 4-Jul-2021

Summary

Official Symbol
ZNF644provided by HGNC
Official Full Name
zinc finger protein 644provided by HGNC
Primary source
HGNC:HGNC:29222
See related
Ensembl:ENSG00000122482 MIM:614159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NatF; MYP21; ZEP-2; BM-005
Summary
The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 9.2), endometrium (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF644 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (90915304..91022267, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91380861..91487592, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1763 Neighboring gene phosphorylase kinase regulatory subunit alpha 1 pseudogene Neighboring gene ribosomal protein L5 pseudogene 6 Neighboring gene helicase for meiosis 1 Neighboring gene flap structure-specific endonuclease 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of the metabolic syndrome in Indian Asian men.
GeneReviews: Not available
Myopia 21, autosomal dominant
MedGen: C3279997 OMIM: 614167 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1221, MGC60165, MGC70410

General protein information

Preferred Names
zinc finger protein 644
Names
zinc finger motif enhancer binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029760.1 RefSeqGene

    Range
    5221..111952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016620.4NP_057704.2  zinc finger protein 644 isoform 2

    See identical proteins and their annotated locations for NP_057704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    AB033047, DA147194
    Consensus CDS
    CCDS732.1
    UniProtKB/Swiss-Prot
    Q9H582
    Related
    ENSP00000340828.5, ENST00000347275.9
  2. NM_032186.5NP_115562.3  zinc finger protein 644 isoform 2

    See identical proteins and their annotated locations for NP_115562.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    AB033047, BI760689
    Consensus CDS
    CCDS732.1
    UniProtKB/Swiss-Prot
    Q9H582
    Related
    ENSP00000354659.5, ENST00000361321.5
  3. NM_201269.3NP_958357.1  zinc finger protein 644 isoform 1

    See identical proteins and their annotated locations for NP_958357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC132776, BC150177, BX477299
    Consensus CDS
    CCDS731.1
    UniProtKB/Swiss-Prot
    Q9H582
    UniProtKB/TrEMBL
    A7E234
    Related
    ENSP00000337008.5, ENST00000337393.10
    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    90915304..91022267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002494.1XP_016857983.1  zinc finger protein 644 isoform X3

    UniProtKB/Swiss-Prot
    Q9H582
  2. XM_017002493.2XP_016857982.1  zinc finger protein 644 isoform X3

    UniProtKB/Swiss-Prot
    Q9H582
  3. XM_017002492.2XP_016857981.1  zinc finger protein 644 isoform X3

    UniProtKB/Swiss-Prot
    Q9H582
  4. XM_011542258.3XP_011540560.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_011540560.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  5. XM_017002489.2XP_016857978.1  zinc finger protein 644 isoform X2

    UniProtKB/Swiss-Prot
    Q9H582
    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  6. XM_017002490.2XP_016857979.1  zinc finger protein 644 isoform X2

    UniProtKB/Swiss-Prot
    Q9H582
    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  7. XM_017002488.2XP_016857977.1  zinc finger protein 644 isoform X2

    UniProtKB/Swiss-Prot
    Q9H582
    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  8. XM_017002491.2XP_016857980.1  zinc finger protein 644 isoform X2

    UniProtKB/Swiss-Prot
    Q9H582
    Related
    ENSP00000359469.1, ENST00000370440.5
    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  9. XM_017002487.2XP_016857976.1  zinc finger protein 644 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  10. XM_011542259.3XP_011540561.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_011540561.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  11. XM_005271257.5XP_005271314.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_005271314.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  12. XM_011542260.3XP_011540562.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_011540562.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  13. XM_005271260.5XP_005271317.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_005271317.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  14. XM_011542261.3XP_011540563.1  zinc finger protein 644 isoform X1

    See identical proteins and their annotated locations for XP_011540563.1

    Conserved Domains (3) summary
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
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