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LACS2 long-chain acyl-CoA synthetase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841367, updated on 18-Sep-2024

Summary

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Official Symbol
LACS2
Official Full Name
long-chain acyl-CoA synthetase 2
Primary source
TAIR:AT1G49430
Locus tag
AT1G49430
See related
Araport:AT1G49430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F13F21.14; F13F21_14; LATERAL ROOT DEVELOPMENT 2; long-chain acyl-CoA synthetase 2; LRD2
Summary
Encodes a long chain acyl-CoA synthetase that catalyzes the synthesis of omega-hydroxy fatty acyl-CoA intermediates in the pathway to cutin synthesis. Required for repression of lateral root formation.
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Genomic context

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See LACS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Sequence:
Chromosome: 1; NC_003070.9 (18290942..18295905)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene translocase of the outer mitochondrial membrane 6 Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene low-molecular-weight cysteine-rich 16 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus. Ding LN, et al. BMC Plant Biol, 2020 Jan 13. PMID 31931712, Free PMC Article
  2. Mutations in LACS2, a long-chain acyl-coenzyme A synthetase, enhance susceptibility to avirulent Pseudomonas syringae but confer resistance to Botrytis cinerea in Arabidopsis. Tang D, et al. Plant Physiol, 2007 Jun. PMID 17434992, Free PMC Article
  3. A permeable cuticle in Arabidopsis leads to a strong resistance to Botrytis cinerea. Bessire M, et al. EMBO J, 2007 Apr 18. PMID 17396154, Free PMC Article
  4. Osmotic regulation of root system architecture. Deak KI, et al. Plant J, 2005 Jul. PMID 15960613
  5. The acyl-CoA synthetase encoded by LACS2 is essential for normal cuticle development in Arabidopsis. Schnurr J, et al. Plant Cell, 2004 Mar. PMID 14973169, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An orthologue of the Arabidopsis LACS2 gene, a long chain acyl-CoA synthetase, BnLACS2, located in the endoplasmic reticulum was identified in B. napus. BnLACS2 transcription increased the expression of genes involved in glycolysis, and FA and lipid synthesis in developing seeds. These results suggested that BnLACS2 is an important factor for seed oil production in B. napus.
    Title: Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus.
  2. Both ABA and LRD2 control root system architecture in the presence or absence of osmotic stress in A. thaliana. [LRD2]
    Title: Osmotic regulation of root system architecture.
  3. lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
    Title: Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis.
  4. mutant highly resistant to Botrytis cinerea
    Title: Mutations in LACS2, a long-chain acyl-coenzyme A synthetase, enhance susceptibility to avirulent Pseudomonas syringae but confer resistance to Botrytis cinerea in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001333383.1
NM_103833.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cutin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lateral root formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wax biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
long-chain acyl-CoA synthetase 2
NP_175368.2
  • long-chain acyl-CoA synthetase 2 (LACS2); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT1G64400.1); Has 53337 Blast hits to 50359 proteins in 3209 species: Archae - 917; Bacteria - 34261; Metazoa - 2388; Fungi - 2032; Plants - 1855; Viruses - 1; Other Eukaryotes - 11883 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18290942..18295905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103833.5 → NP_175368.2  long-chain acyl-CoA synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175368.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XIA9
    UniProtKB/TrEMBL
    A0A178W3L9, A0A5S9WNG6, A0A654ESQ6
    Conserved Domains (1) summary
    PLN02861
    Location:3 → 665
    PLN02861; long-chain-fatty-acid-CoA ligase

  2. NM_001333383.1 → NP_001321632.1  long-chain acyl-CoA synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARJ4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XIA9.1

Gene LinkOut

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