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TOMM40L translocase of outer mitochondrial membrane 40 like [ Homo sapiens (human) ]

Gene ID: 84134, updated on 1-Jun-2020

Summary

Official Symbol
TOMM40Lprovided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 40 likeprovided by HGNC
Primary source
HGNC:HGNC:25756
See related
Ensembl:ENSG00000158882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOMM40B
Expression
Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 24 other tissues See more
Orthologs

Genomic context

See TOMM40L in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161225939..161230746)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161195729..161200536)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc fragment of IgE receptor Ig Neighboring gene apolipoprotein A2 Neighboring gene microRNA 5187 Neighboring gene nuclear receptor subfamily 1 group I member 3 Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene uncharacterized LOC105371472 Neighboring gene uncharacterized LOC107985221

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12770

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mitochondrion targeting sequence binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
porin activity IEA
Inferred from Electronic Annotation
more info
 
preprotein binding IEA
Inferred from Electronic Annotation
more info
 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pore complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM40B
Names
protein TOMM40-like
translocase of outer mitochondrial membrane 40 homolog-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286373.1NP_001273302.1  mitochondrial import receptor subunit TOM40B isoform 2

    See identical proteins and their annotated locations for NP_001273302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK297848, AL590714, CA411898, DA199234
    Consensus CDS
    CCDS65700.1
    UniProtKB/Swiss-Prot
    Q969M1
    Related
    ENSP00000443233.1, ENST00000545897.5
    Conserved Domains (1) summary
    cd07305
    Location:24274
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
  2. NM_001286374.2NP_001273303.1  mitochondrial import receptor subunit TOM40B isoform 3

    See identical proteins and their annotated locations for NP_001273303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frmae exons in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL523459, AL590714, CA411898, DA199234
    Related
    ENST00000474486.5
    Conserved Domains (1) summary
    cd07305
    Location:24243
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
  3. NM_032174.6NP_115550.2  mitochondrial import receptor subunit TOM40B isoform 1

    See identical proteins and their annotated locations for NP_115550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK027704, AL590714, CA411898
    Consensus CDS
    CCDS1227.1
    UniProtKB/Swiss-Prot
    Q969M1
    Related
    ENSP00000356967.3, ENST00000367988.8
    Conserved Domains (1) summary
    cd07305
    Location:24308
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161225939..161230746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711572.2XP_006711635.1  mitochondrial import receptor subunit TOM40B isoform X1

    See identical proteins and their annotated locations for XP_006711635.1

    UniProtKB/Swiss-Prot
    Q969M1
    Conserved Domains (1) summary
    cd07305
    Location:24308
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
  2. XM_017002482.2XP_016857971.1  mitochondrial import receptor subunit TOM40B isoform X2

    UniProtKB/Swiss-Prot
    Q969M1
    Conserved Domains (1) summary
    cd07305
    Location:24274
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
  3. XM_017002481.1XP_016857970.1  mitochondrial import receptor subunit TOM40B isoform X1

    UniProtKB/Swiss-Prot
    Q969M1
    Conserved Domains (1) summary
    cd07305
    Location:24308
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
  4. XM_011510057.2XP_011508359.1  mitochondrial import receptor subunit TOM40B isoform X3

    See identical proteins and their annotated locations for XP_011508359.1

    Conserved Domains (1) summary
    cd07305
    Location:24243
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
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