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USP42 ubiquitin specific peptidase 42 [ Homo sapiens (human) ]

Gene ID: 84132, updated on 6-Sep-2022

Summary

Official Symbol
USP42provided by HGNC
Official Full Name
ubiquitin specific peptidase 42provided by HGNC
Primary source
HGNC:HGNC:20068
See related
Ensembl:ENSG00000106346 AllianceGenome:HGNC:20068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.2), bone marrow (RPKM 4.1) and 24 other tissues See more
Orthologs
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Genomic context

See USP42 in Genome Data Viewer
Location:
7p22.1
Exon count:
31
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6081241..6161564)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6224323..6280940)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6144580..6201195)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene Neighboring gene RNA, U6 small nuclear 218, pseudogene Neighboring gene cytohesin 3 Neighboring gene Sharpr-MPRA regulatory region 15593 Neighboring gene family with sequence similarity 220 member A Neighboring gene salivary gland specific protein SAGSIN1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12697, AC004895.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 42
Names
deubiquitinating enzyme 42
ubiquitin specific protease 42
ubiquitin thioesterase 42
ubiquitin thiolesterase 42
ubiquitin-specific-processing protease 42
NP_001352693.1
NP_001376579.1
NP_115548.1
XP_005249940.1
XP_006715854.1
XP_011513875.1
XP_024302736.1
XP_024302737.1
XP_047276891.1
XP_047276892.1
XP_047276893.1
XP_047276894.1
XP_047276895.1
XP_047276896.1
XP_047276897.1
XP_047276898.1
XP_047276899.1
XP_047276900.1
XP_047276901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365764.1NP_001352693.1  ubiquitin carboxyl-terminal hydrolase 42 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004895, AY618868, HY052239
    UniProtKB/Swiss-Prot
    Q6P9B4
    Related
    ENST00000479544.6
    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  2. NM_001389650.1NP_001376579.1  ubiquitin carboxyl-terminal hydrolase 42 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004895
    Conserved Domains (4) summary
    PHA03247
    Location:422938
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:735940
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12678
    Location:8461113
    PRK12678; transcription termination factor Rho; Provisional
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  3. NM_032172.3NP_115548.1  ubiquitin carboxyl-terminal hydrolase 42 isoform 2

    See identical proteins and their annotated locations for NP_115548.1

    Status: VALIDATED

    Source sequence(s)
    AA936550, BC132862, BF725643, BM995466, DB457216
    Consensus CDS
    CCDS47535.1
    UniProtKB/Swiss-Prot
    Q9H9J4
    Related
    ENSP00000301962.5, ENST00000306177.10
    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6081241..6161564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420940.1XP_047276896.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  2. XM_047420938.1XP_047276894.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  3. XM_024446969.2XP_024302737.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:422938
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:735940
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12678
    Location:8461113
    PRK12678; transcription termination factor Rho; Provisional
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  4. XM_024446968.2XP_024302736.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:422938
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:735940
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12678
    Location:8461113
    PRK12678; transcription termination factor Rho; Provisional
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  5. XM_047420939.1XP_047276895.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  6. XM_011515573.2XP_011513875.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_011513875.1

    Conserved Domains (4) summary
    PHA03247
    Location:422938
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:735940
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12678
    Location:8461113
    PRK12678; transcription termination factor Rho; Provisional
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  7. XM_047420942.1XP_047276898.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  8. XM_047420935.1XP_047276891.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  9. XM_047420936.1XP_047276892.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  10. XM_047420937.1XP_047276893.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  11. XM_006715791.2XP_006715854.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_006715854.1

    Conserved Domains (4) summary
    PHA03247
    Location:422938
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:735940
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12678
    Location:8461113
    PRK12678; transcription termination factor Rho; Provisional
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  12. XM_005249883.6XP_005249940.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X4

    Conserved Domains (2) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:111409
    UCH; Ubiquitin carboxyl-terminal hydrolase
  13. XM_047420941.1XP_047276897.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

  14. XM_047420943.1XP_047276899.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X2

  15. XM_047420944.1XP_047276900.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X3

    Related
    ENSP00000408217.2, ENST00000426246.2
  16. XM_047420945.1XP_047276901.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6224323..6280940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)