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USP42 ubiquitin specific peptidase 42 [ Homo sapiens (human) ]

Gene ID: 84132, updated on 18-Aug-2020

Summary

Official Symbol
USP42provided by HGNC
Official Full Name
ubiquitin specific peptidase 42provided by HGNC
Primary source
HGNC:HGNC:20068
See related
Ensembl:ENSG00000106346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 9.2), bone marrow (RPKM 4.1) and 24 other tissues See more
Orthologs

Genomic context

See USP42 in Genome Data Viewer
Location:
7p22.1
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (6078743..6161564)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6144550..6201195)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene Neighboring gene RNA, U6 small nuclear 218, pseudogene Neighboring gene cytohesin 3 Neighboring gene family with sequence similarity 220 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12697, AC004895.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 42
Names
deubiquitinating enzyme 42
ubiquitin specific protease 42
ubiquitin thioesterase 42
ubiquitin thiolesterase 42
ubiquitin-specific-processing protease 42
NP_001352693.1
NP_115548.1
XP_005249940.1
XP_006715853.1
XP_006715854.1
XP_011513875.1
XP_011513876.1
XP_011513879.1
XP_011513880.1
XP_024302736.1
XP_024302737.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365764.1NP_001352693.1  ubiquitin carboxyl-terminal hydrolase 42 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004895, AY618868, HY052239
    Related
    ENST00000479544.6
    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  2. NM_032172.3NP_115548.1  ubiquitin carboxyl-terminal hydrolase 42 isoform 2

    See identical proteins and their annotated locations for NP_115548.1

    Status: VALIDATED

    Source sequence(s)
    AA936550, BC132862, BF725643, BM995466, DB457216
    Consensus CDS
    CCDS47535.1
    UniProtKB/Swiss-Prot
    Q9H9J4
    Related
    ENSP00000301962.5, ENST00000306177.9
    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    6078743..6161564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446969.1XP_024302737.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  2. XM_024446968.1XP_024302736.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  3. XM_011515573.1XP_011513875.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_011513875.1

    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  4. XM_006715791.2XP_006715854.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_006715854.1

    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  5. XM_011515574.1XP_011513876.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X2

    Conserved Domains (3) summary
    cd02661
    Location:38299
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:43298
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02275
    Location:907967
    RcnB; Nickel/cobalt transporter regulator
  6. XM_006715790.2XP_006715853.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_006715853.1

    Conserved Domains (4) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26386
    Location:735940
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:422938
    Atrophin-1; Atrophin-1 family
    cl28310
    Location:8461113
    Rho; Transcription termination factor Rho [Transcription]
  7. XM_005249883.5XP_005249940.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X5

    Conserved Domains (2) summary
    cd02661
    Location:110410
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:111409
    UCH; Ubiquitin carboxyl-terminal hydrolase
  8. XM_011515578.1XP_011513880.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X4

    Related
    ENSP00000408217.2, ENST00000426246.2
    Conserved Domains (3) summary
    cd02661
    Location:1256
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1255
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02275
    Location:864924
    RcnB; Nickel/cobalt transporter regulator
  9. XM_011515577.1XP_011513879.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X3

    See identical proteins and their annotated locations for XP_011513879.1

    Conserved Domains (3) summary
    cd02661
    Location:3264
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:8263
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02275
    Location:872932
    RcnB; Nickel/cobalt transporter regulator

RNA

  1. XR_002956494.1 RNA Sequence

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