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ACAD11 acyl-CoA dehydrogenase family member 11 [ Homo sapiens (human) ]

Gene ID: 84129, updated on 5-Sep-2021

Summary

Official Symbol
ACAD11provided by HGNC
Official Full Name
acyl-CoA dehydrogenase family member 11provided by HGNC
Primary source
HGNC:HGNC:30211
See related
Ensembl:ENSG00000240303 MIM:614288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACAD-11
Summary
This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in kidney (RPKM 25.3), liver (RPKM 24.9) and 25 other tissues See more
Orthologs
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Genomic context

See ACAD11 in Genome Data Viewer
Location:
3q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (132558141..132659809, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132276985..132378653, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NIP7 pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene NPHP3-ACAD11 readthrough (NMD candidate) Neighboring gene atypical chemokine receptor 4 Neighboring gene heat shock protein family A (Hsp70) member pseudogene 19 Neighboring gene ubiquitin like modifier activating enzyme 5 Neighboring gene nephrocystin 3 Neighboring gene NPHP3 antisense RNA 1 Neighboring gene uncharacterized LOC105374115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough NPHP3-ACAD11

Readthrough gene: NPHP3-ACAD11, Included gene: NPHP3

Homology

Clone Names

  • FLJ12592, MGC150619

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
acyl-CoA dehydrogenase family member 11
Names
acyl-Coenzyme A dehydrogenase family, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042830.1 RefSeqGene

    Range
    5323..106991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032169.5NP_115545.3  acyl-CoA dehydrogenase family member 11

    See identical proteins and their annotated locations for NP_115545.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AI091999, BC125204
    Consensus CDS
    CCDS3074.1
    UniProtKB/Swiss-Prot
    Q709F0
    Related
    ENSP00000264990.6, ENST00000264990.11
    Conserved Domains (1) summary
    cl25414
    Location:11770
    Acyl-CoA_dh_M; Acyl-CoA dehydrogenase, middle domain

RNA

  1. NR_132426.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal segment compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL833721, DA804241
    Related
    ENST00000496418.5
  2. NR_132427.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal segment and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020632, AL832873, BC125204, CB240680
  3. NR_132428.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC125205, CB240680
    Related
    ENST00000485198.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    132558141..132659809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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