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ZNF394 zinc finger protein 394 [ Homo sapiens (human) ]

Gene ID: 84124, updated on 24-Nov-2020

Summary

Official Symbol
ZNF394provided by HGNC
Official Full Name
zinc finger protein 394provided by HGNC
Primary source
HGNC:HGNC:18832
See related
Ensembl:ENSG00000160908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN46; ZKSCAN14
Summary
The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016]
Expression
Broad expression in bone marrow (RPKM 26.0), spleen (RPKM 6.3) and 24 other tissues See more
Orthologs

Genomic context

See ZNF394 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99486519..99500281, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99084142..99097925, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene ATP synthase membrane subunit f Neighboring gene tRNA-Trp (anticodon CCA) 5-1 Neighboring gene zinc finger protein 789 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ12298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 394
Names
zinc finger protein 99
zinc finger protein with KRAB and SCAN domains 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345967.2NP_001332896.1  zinc finger protein 394 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC073063
    Consensus CDS
    CCDS87524.1
    UniProtKB/Swiss-Prot
    Q53GI3
    Related
    ENSP00000409565.2, ENST00000426306.2
  2. NM_001345968.2NP_001332897.1  zinc finger protein 394 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC073063
  3. NM_032164.4NP_115540.2  zinc finger protein 394 isoform 1

    See identical proteins and their annotated locations for NP_115540.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC051847, DA962329
    Consensus CDS
    CCDS5666.1
    UniProtKB/Swiss-Prot
    Q53GI3
    Related
    ENSP00000337363.6, ENST00000337673.7
    Conserved Domains (6) summary
    smart00431
    Location:60170
    SCAN; leucine rich region
    COG5048
    Location:356420
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:464543
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:414436
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:155214
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99486519..99500281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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