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QRFPR pyroglutamylated RFamide peptide receptor [ Homo sapiens (human) ]

Gene ID: 84109, updated on 7-Oct-2019


Official Symbol
QRFPRprovided by HGNC
Official Full Name
pyroglutamylated RFamide peptide receptorprovided by HGNC
Primary source
See related
Ensembl:ENSG00000186867 MIM:606925
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AQ27; GPR103; SP9155
Low expression observed in reference dataset See more

Genomic context

See QRFPR in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121328642..121381054, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122249797..122302181, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377400 Neighboring gene TNFAIP3 interacting protein 3 Neighboring gene RNA, U6 small nuclear 948, pseudogene Neighboring gene KIAA1191 pseudogene Neighboring gene uncharacterized LOC107986309 Neighboring gene tubulin beta 4B class IVb pseudogene 5 Neighboring gene uncharacterized LOC107986310

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystem (from REACTOME)
    Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystemThe orphan G protein-coupled receptors mentioned here regulate sleep and appetite.
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC149217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
integral component of membrane IC
Inferred by Curator
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
pyroglutamylated RF-amide peptide receptor
G-protein coupled receptor 103
QRFP receptor
orexigenic neuropeptide QRFP receptor
peptide P518 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198179.3NP_937822.2  pyroglutamylated RF-amide peptide receptor

    See identical proteins and their annotated locations for NP_937822.2

    Status: VALIDATED

    Source sequence(s)
    AB109629, AC093867, BG169612, DA461055
    Consensus CDS
    ENSP00000377948.2, ENST00000394427.3
    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    121328642..121381054 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008693.2XP_016864182.1  pyroglutamylated RF-amide peptide receptor isoform X1

    ENSP00000423369.1, ENST00000507331.5
    Conserved Domains (2) summary
    7tm_GPCRs; TM helix 1 [structural motif]
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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