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PRAM1 PML-RARA regulated adaptor molecule 1 [ Homo sapiens (human) ]

Gene ID: 84106, updated on 9-Aug-2020

Summary

Official Symbol
PRAM1provided by HGNC
Official Full Name
PML-RARA regulated adaptor molecule 1provided by HGNC
Primary source
HGNC:HGNC:30091
See related
Ensembl:ENSG00000133246 MIM:606466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRAM-1; PML-RAR
Summary
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues See more
Orthologs

Genomic context

See PRAM1 in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8490055..8502640, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8554940..8567538, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene zinc finger protein 414 Neighboring gene myosin IF

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC39864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neutrophil degranulation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PML-RARA-regulated adapter molecule 1
Names
PML-RARA target gene encoding an Adaptor Molecule-1
PRAM

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032152.5NP_115528.4  PML-RARA-regulated adapter molecule 1

    See identical proteins and their annotated locations for NP_115528.4

    Status: REVIEWED

    Source sequence(s)
    AC092298, AJ272324, AK308227, BC028012, DA350460
    Consensus CDS
    CCDS45954.2
    UniProtKB/Swiss-Prot
    Q96QH2
    Related
    ENSP00000408342.2, ENST00000423345.5
    Conserved Domains (2) summary
    pfam14603
    Location:577655
    hSH3; Helically-extended SH3 domain
    cl26464
    Location:56412
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8490055..8502640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272502.2XP_005272559.1  PML-RARA-regulated adapter molecule 1 isoform X2

    Conserved Domains (1) summary
    pfam14603
    Location:582655
    hSH3; Helically-extended SH3 domain
  2. XM_011528352.2XP_011526654.1  PML-RARA-regulated adapter molecule 1 isoform X1

    Conserved Domains (1) summary
    pfam14603
    Location:584657
    hSH3; Helically-extended SH3 domain
  3. XM_011528353.2XP_011526655.1  PML-RARA-regulated adapter molecule 1 isoform X3

    Conserved Domains (1) summary
    pfam14603
    Location:584665
    hSH3; Helically-extended SH3 domain
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