Format

Send to:

Choose Destination

MCM2 minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841056, updated on 18-Nov-2018

Summary

Gene symbol
MCM2
Gene description
minichromosome maintenance (MCM2/3/5) family protein
Primary source
Araport:AT1G44900
Locus tag
AT1G44900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMCM2; MINICHROMOSOME MAINTENANCE 2; T12C22.19; T12C22_19
Summary
Encodes MCM2 (MINICHROMOSOME MAINTENANCE 2), a protein essential to embryo development. Overexpression results in altered root meristem function.

Genomic context

See MCM2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (16970214..16974753)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene inner membrane OXA1-like protein Neighboring gene minichromosone maintenance protein Neighboring gene pre-mRNA-processing protein 40A Neighboring gene transmembrane protein Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MCM2 gene: The MCM2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
  • Orthologs
NM_001198225.2
NM_103572.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-dependent ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA unwinding involved in DNA replication TAS
Traceable Author Statement
more info
PubMed 
embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
root development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MCM complex IEA
Inferred from Electronic Annotation
more info
 
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
minichromosome maintenance (MCM2/3/5) family protein
NP_001185154.1
  • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1).
NP_175112.2
  • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1); Has 6038 Blast hits to 5672 proteins in 1024 species: Archae - 381; Bacteria - 1139; Metazoa - 1602; Fungi - 1087; Plants - 469; Viruses - 28; Other Eukaryotes - 1332 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    16970214..16974753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198225.2NP_001185154.1  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4HPK7
    Conserved Domains (4) summary
    smart00350
    Location:318826
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:67136
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:219334
    MCM_N; MCM N-terminal domain
    cl21455
    Location:542681
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_103572.5NP_175112.2  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175112.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LPD9
    Conserved Domains (4) summary
    smart00350
    Location:320828
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:67138
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:221336
    MCM_N; MCM N-terminal domain
    cl21455
    Location:544683
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Support Center