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USP44 ubiquitin specific peptidase 44 [ Homo sapiens (human) ]

Gene ID: 84101, updated on 11-Jul-2021

Summary

Official Symbol
USP44provided by HGNC
Official Full Name
ubiquitin specific peptidase 44provided by HGNC
Primary source
HGNC:HGNC:20064
See related
Ensembl:ENSG00000136014 MIM:610993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]
Expression
Biased expression in testis (RPKM 9.0), lung (RPKM 1.3) and 1 other tissue See more
Orthologs
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Genomic context

See USP44 in Genome Data Viewer
Location:
12q22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (95516560..95551529, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95910336..95945252, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 26 Neighboring gene methionyl aminopeptidase 2 Neighboring gene phosphoglycerate mutase 1 pseudogene 5 Neighboring gene netrin 4 Neighboring gene uncharacterized LOC105369919

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14528, DKFZp434D0127

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol-dependent deubiquitinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thiol-dependent deubiquitinase TAS
Traceable Author Statement
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 44
Names
deubiquitinating enzyme 44
ubiquitin specific protease 44
ubiquitin thioesterase 44
ubiquitin thiolesterase 44
ubiquitin-specific-processing protease 44
NP_001035862.1
NP_001265322.1
NP_001334865.1
NP_001334866.1
NP_115523.2
XP_005269229.1
XP_005269230.1
XP_005269231.1
XP_011537102.1
XP_011537103.1
XP_011537104.1
XP_011537105.1
XP_011537106.1
XP_011537107.1
XP_011537108.1
XP_016875499.1
XP_016875501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052622.1 RefSeqGene

    Range
    5054..39970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042403.3NP_001035862.1  ubiquitin carboxyl-terminal hydrolase 44

    See identical proteins and their annotated locations for NP_001035862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the same protein as variants 1, 3, 4, and 6.
    Source sequence(s)
    AC018475, AK027434, AK315697, BM023146, DA092275, DB462518
    Consensus CDS
    CCDS9053.1
    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
    Related
    ENSP00000376806.2, ENST00000393091.6
    Conserved Domains (3) summary
    cl02553
    Location:274676
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272675
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. NM_001278393.2NP_001265322.1  ubiquitin carboxyl-terminal hydrolase 44

    See identical proteins and their annotated locations for NP_001265322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the same protein as variants 1, 2, 5, and 6.
    Source sequence(s)
    AC018475, AK027434, AK315697, BM023146, DA092275, DB454726
    Consensus CDS
    CCDS9053.1
    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
    Related
    ENSP00000442629.2, ENST00000537435.2
    Conserved Domains (3) summary
    cl02553
    Location:274676
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272675
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  3. NM_001347936.2NP_001334865.1  ubiquitin carboxyl-terminal hydrolase 44

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the same protein as variants 1, 2, 3, and 6.
    Source sequence(s)
    AC018475
    Consensus CDS
    CCDS9053.1
    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
  4. NM_001347937.2NP_001334866.1  ubiquitin carboxyl-terminal hydrolase 44

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the same protein as variants 1, 2, 3, and 5.
    Source sequence(s)
    AC018475
    Consensus CDS
    CCDS9053.1
    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
  5. NM_032147.5NP_115523.2  ubiquitin carboxyl-terminal hydrolase 44

    See identical proteins and their annotated locations for NP_115523.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2, 3, 5, and 6.
    Source sequence(s)
    AC018475, AK315697, BM023146, DA092275, DB443014, DB456039
    Consensus CDS
    CCDS9053.1
    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
    Related
    ENSP00000258499.3, ENST00000258499.8
    Conserved Domains (3) summary
    cl02553
    Location:274676
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272675
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RNA

  1. NR_125360.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018475
  2. NR_144944.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018475
  3. NR_144945.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018475
  4. NR_144946.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018475
  5. NR_144947.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018475
  6. NR_144948.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018475

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    95516560..95551529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538803.1XP_011537105.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537105.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. XM_005269172.1XP_005269229.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_005269229.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  3. XM_011538800.2XP_011537102.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537102.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  4. XM_011538805.2XP_011537107.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537107.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  5. XM_005269174.1XP_005269231.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_005269231.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  6. XM_011538801.1XP_011537103.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537103.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  7. XM_011538804.2XP_011537106.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537106.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  8. XM_005269173.1XP_005269230.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_005269230.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  9. XM_011538802.1XP_011537104.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    See identical proteins and their annotated locations for XP_011537104.1

    Conserved Domains (3) summary
    cl02553
    Location:274707
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272706
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  10. XM_017020010.2XP_016875499.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    UniProtKB/Swiss-Prot
    Q9H0E7
    UniProtKB/TrEMBL
    A0A024RBD7
    Conserved Domains (3) summary
    cl02553
    Location:274676
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:272675
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  11. XM_017020012.1XP_016875501.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X3

  12. XM_011538806.2XP_011537108.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X4

    Conserved Domains (3) summary
    cd02257
    Location:421496
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:274438
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:2990
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RNA

  1. XR_001748887.1 RNA Sequence

  2. XR_944757.1 RNA Sequence

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