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UXT ubiquitously expressed prefoldin like chaperone [ Homo sapiens (human) ]

Gene ID: 8409, updated on 22-Sep-2022

Summary

Official Symbol
UXTprovided by HGNC
Official Full Name
ubiquitously expressed prefoldin like chaperoneprovided by HGNC
Primary source
HGNC:HGNC:12641
See related
Ensembl:ENSG00000126756 MIM:300234; AllianceGenome:HGNC:12641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAP1; ART-27
Summary
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues See more
Orthologs
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Genomic context

See UXT in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47651796..47659180, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47061699..47069083, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47511195..47518579, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene ETS transcription factor ELK1 Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element Neighboring gene CRISPRi-validated cis-regulatory element chrX.881 Neighboring gene UXT antisense RNA 1 Neighboring gene CXXC finger protein 1 pseudogene 1 Neighboring gene SMS pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperone complex IC
Inferred by Curator
more info
PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein UXT
Names
SKP2-associated alpha PFD 1
androgen receptor trapped clone 27 protein
ubiquitously expressed transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004182.4NP_004173.1  protein UXT isoform 2

    See identical proteins and their annotated locations for NP_004173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF092737, BQ681820, DA372561
    Consensus CDS
    CCDS14285.1
    UniProtKB/Swiss-Prot
    Q9UBK9, Q9Y6E5
    Related
    ENSP00000327797.3, ENST00000333119.7
    Conserved Domains (1) summary
    cd00584
    Location:18147
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
  2. NM_153477.3NP_705582.1  protein UXT isoform 1

    See identical proteins and their annotated locations for NP_705582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF083242, BQ681820, DA372561
    Consensus CDS
    CCDS14284.1
    UniProtKB/Swiss-Prot
    Q9UBK9
    Related
    ENSP00000337393.2, ENST00000335890.3
    Conserved Domains (1) summary
    cd00584
    Location:30159
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RNA

  1. NR_045559.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF083242, BM471483, BQ681820, DA372561
    Related
    ENST00000485641.5
  2. NR_045560.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BQ681820, DA372561, EL949569

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    47651796..47659180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    47061699..47069083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)