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UXT ubiquitously expressed prefoldin like chaperone [ Homo sapiens (human) ]

Gene ID: 8409, updated on 7-Oct-2018

Summary

Official Symbol
UXTprovided by HGNC
Official Full Name
ubiquitously expressed prefoldin like chaperoneprovided by HGNC
Primary source
HGNC:HGNC:12641
See related
Ensembl:ENSG00000126756 MIM:300234; Vega:OTTHUMG00000021453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAP1; ART-27
Summary
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues See more
Orthologs

Genomic context

See UXT in Genome Data Viewer
Location:
Xp11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (47651792..47659180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47511191..47518579, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene ELK1, ETS transcription factor Neighboring gene UXT antisense RNA 1 Neighboring gene CXXC finger protein 1 pseudogene 1 Neighboring gene spermine synthase pseudogene Neighboring gene zinc finger protein 585A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with gamma-tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein UXT
Names
SKP2-associated alpha PFD 1
androgen receptor trapped clone 27 protein
ubiquitously expressed transcript protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004182.3NP_004173.1  protein UXT isoform 2

    See identical proteins and their annotated locations for NP_004173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF092737, BQ681820, DA372561
    Consensus CDS
    CCDS14285.1
    UniProtKB/Swiss-Prot
    Q9UBK9
    Related
    ENSP00000327797.3, OTTHUMP00000023226, ENST00000333119.7, OTTHUMT00000056440
    Conserved Domains (1) summary
    cd00584
    Location:18147
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
  2. NM_153477.2NP_705582.1  protein UXT isoform 1

    See identical proteins and their annotated locations for NP_705582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF083242, BQ681820, DA372561
    Consensus CDS
    CCDS14284.1
    UniProtKB/Swiss-Prot
    Q9UBK9
    Related
    ENSP00000337393.2, OTTHUMP00000023227, ENST00000335890.2, OTTHUMT00000056441
    Conserved Domains (1) summary
    cd00584
    Location:30159
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RNA

  1. NR_045559.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF083242, BM471483, BQ681820, DA372561
    Related
    ENST00000485641.5, OTTHUMT00000056444
  2. NR_045560.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BQ681820, DA372561, EL949569

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    47651792..47659180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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