Format

Send to:

Choose Destination

FAM186B family with sequence similarity 186 member B [ Homo sapiens (human) ]

Gene ID: 84070, updated on 23-Nov-2021

Summary

Official Symbol
FAM186Bprovided by HGNC
Official Full Name
family with sequence similarity 186 member Bprovided by HGNC
Primary source
HGNC:HGNC:25296
See related
Ensembl:ENSG00000135436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf25
Summary
This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward testis (RPKM 21.1) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FAM186B in Genome Data Viewer
Location:
12q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49582873..49605709, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49976656..49999422, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369761 Neighboring gene potassium voltage-gated channel subfamily H member 3 Neighboring gene microspherule protein 1 Neighboring gene RNA, U6 small nuclear 834, pseudogene Neighboring gene RNA polymerase II subunit K pseudogene 1 Neighboring gene PARK7 pseudogene 1 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 9 Neighboring gene pre-mRNA processing factor 40 homolog B Neighboring gene formin like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434J0113, DKFZp434N2350

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032130.3NP_115506.1  protein FAM186B

    See identical proteins and their annotated locations for NP_115506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein coding transcript.
    Source sequence(s)
    AL136748, DB087952
    Consensus CDS
    CCDS8788.1
    UniProtKB/Swiss-Prot
    Q8IYM0
    UniProtKB/TrEMBL
    A0A024R129
    Related
    ENSP00000257894.2, ENST00000257894.2
    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)

RNA

  1. NR_027450.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site in the first exon, and also contains an alternate 3' terminal exon, compared to variant 1. It is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020612, AI829695, AK302702, AL136748, DC402111
    Related
    ENST00000533372.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49582873..49605709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020008.2XP_016875497.1  protein FAM186B isoform X4

  2. XM_006719626.2XP_006719689.1  protein FAM186B isoform X2

    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)
  3. XM_006719625.2XP_006719688.1  protein FAM186B isoform X1

    See identical proteins and their annotated locations for XP_006719688.1

    UniProtKB/Swiss-Prot
    Q8IYM0
    UniProtKB/TrEMBL
    A0A024R129
    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)
  4. XM_011538797.3XP_011537099.1  protein FAM186B isoform X5

    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)
  5. XM_006719627.3XP_006719690.1  protein FAM186B isoform X3

    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)
  6. XM_011538796.2XP_011537098.1  protein FAM186B isoform X1

    See identical proteins and their annotated locations for XP_011537098.1

    UniProtKB/Swiss-Prot
    Q8IYM0
    UniProtKB/TrEMBL
    A0A024R129
    Conserved Domains (1) summary
    pfam11843
    Location:484578
    DUF3363; Protein of unknown function (DUF3363)
Support Center