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FAM160A2 family with sequence similarity 160 member A2 [ Homo sapiens (human) ]

Gene ID: 84067, updated on 8-Nov-2020

Summary

Official Symbol
FAM160A2provided by HGNC
Official Full Name
family with sequence similarity 160 member A2provided by HGNC
Primary source
HGNC:HGNC:25378
See related
Ensembl:ENSG00000051009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHIP; C11orf56
Summary
The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in small intestine (RPKM 16.8), duodenum (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See FAM160A2 in Genome Data Viewer
Location:
11p15.4
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6211338..6234663, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6232564..6255941, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene chromosome 11 open reading frame 42 Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene cholecystokinin B receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22665, KIAA1759, DKFZp566M1046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
FHF complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FTS and Hook-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052832.1 RefSeqGene

    Range
    5076..28367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098794.2NP_001092264.1  FTS and Hook-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001092264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AB051546, BC030825, DA389621
    Consensus CDS
    CCDS44530.1
    UniProtKB/Swiss-Prot
    Q8N612
    Related
    ENSP00000416918.2, ENST00000449352.6
    Conserved Domains (2) summary
    pfam04814
    Location:454567
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein
  2. NM_032127.4NP_115503.2  FTS and Hook-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_115503.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB051546, AL136723, DA389621
    Consensus CDS
    CCDS7760.1
    UniProtKB/Swiss-Prot
    Q8N612
    Related
    ENSP00000265978.4, ENST00000265978.8
    Conserved Domains (2) summary
    pfam04814
    Location:454581
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6211338..6234663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718343.3XP_006718406.1  FTS and Hook-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006718406.1

    UniProtKB/Swiss-Prot
    Q8N612
    Conserved Domains (2) summary
    pfam04814
    Location:454581
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein
  2. XM_011520397.2XP_011518699.1  FTS and Hook-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011518699.1

    UniProtKB/Swiss-Prot
    Q8N612
    Conserved Domains (2) summary
    pfam04814
    Location:454581
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein
  3. XM_024448710.1XP_024304478.1  FTS and Hook-interacting protein isoform X3

    Conserved Domains (2) summary
    pfam04814
    Location:454567
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein
  4. XM_011520398.3XP_011518700.1  FTS and Hook-interacting protein isoform X2

    Conserved Domains (2) summary
    pfam04814
    Location:454581
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    pfam10257
    Location:97426
    RAI16-like; Retinoic acid induced 16-like protein

RNA

  1. XR_002957205.1 RNA Sequence

  2. XR_001747999.2 RNA Sequence

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