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TMEM222 transmembrane protein 222 [ Homo sapiens (human) ]

Gene ID: 84065, updated on 22-Sep-2022

Summary

Official Symbol
TMEM222provided by HGNC
Official Full Name
transmembrane protein 222provided by HGNC
Primary source
HGNC:HGNC:25363
See related
Ensembl:ENSG00000186501 MIM:619469; AllianceGenome:HGNC:25363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf160; NEDMOSBA
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 11.2), testis (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM222 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27322163..27336400)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27163397..27177637)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27648654..27662891)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene WDTC1 divergent transcript Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene actin gamma 1 pseudogene 20 Neighboring gene RNA, U6 small nuclear 48, pseudogene Neighboring gene synaptotagmin like 1 Neighboring gene mitogen-activated protein kinase kinase kinase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111002, DKFZp564D0478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032125.3NP_115501.2  transmembrane protein 222

    See identical proteins and their annotated locations for NP_115501.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a protein.
    Source sequence(s)
    BC090039, DC424669
    Consensus CDS
    CCDS297.2
    UniProtKB/Swiss-Prot
    Q5FVE9, Q9H0R3
    Related
    ENSP00000363189.4, ENST00000374076.9
    Conserved Domains (1) summary
    pfam05608
    Location:61178
    DUF778; Protein of unknown function (DUF778)

RNA

  1. NR_037576.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon which includes an internal stop codon compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so will probably not make a protein.
    Source sequence(s)
    BC090039, DC424669
    Related
    ENST00000464720.5
  2. NR_037577.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon which includes an internal stop codon compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so will probably not make a protein.
    Source sequence(s)
    BC090039, BP326836, BX394857
  3. NR_037580.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has two additional exons, one of which includes an internal stop codon compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so will probably not make a protein.
    Source sequence(s)
    BC090039, BQ927627, DC424669

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    27322163..27336400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431775.1XP_047287731.1  transmembrane protein 222 isoform X1

RNA

  1. XR_001737477.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27163397..27177637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)