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HDHD2 haloacid dehalogenase like hydrolase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 84064, updated on 21-Dec-2019

Summary

Official Symbol
HDHD2provided by HGNC
Official Full Name
haloacid dehalogenase like hydrolase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25364
See related
Ensembl:ENSG00000167220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-301; 3110052N05Rik
Expression
Ubiquitous expression in brain (RPKM 11.6), thyroid (RPKM 10.9) and 25 other tissues See more
Orthologs

Genomic context

See HDHD2 in Genome Data Viewer
Location:
18q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (47107410..47150520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44633781..44676891, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene elongin A2 Neighboring gene uncharacterized LOC105372098 Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene SKI family transcriptional corepressor 2 Neighboring gene RNA, U6 small nuclear 1131, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564D1378

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
haloacid dehalogenase-like hydrolase domain-containing protein 2
Names
epididymis secretory protein Li 301
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318765.2NP_001305694.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC012254, AC051635
    UniProtKB/Swiss-Prot
    Q9H0R4
    Conserved Domains (1) summary
    cl21460
    Location:1165
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_032124.5NP_115500.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_115500.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC012254, AC051635
    Consensus CDS
    CCDS32829.1
    UniProtKB/Swiss-Prot
    Q9H0R4
    UniProtKB/TrEMBL
    V9HW73
    Related
    ENSP00000300605.4, ENST00000300605.11
    Conserved Domains (1) summary
    cd07509
    Location:8255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    47107410..47150520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526228.3XP_011524530.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011524530.1

    UniProtKB/Swiss-Prot
    Q9H0R4
    UniProtKB/TrEMBL
    V9HW73
    Conserved Domains (1) summary
    cd07509
    Location:8255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
  2. XM_011526227.2XP_011524529.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011524529.1

    UniProtKB/Swiss-Prot
    Q9H0R4
    UniProtKB/TrEMBL
    V9HW73
    Conserved Domains (1) summary
    cd07509
    Location:8255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
  3. XM_017026039.1XP_016881528.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H0R4
    UniProtKB/TrEMBL
    V9HW73
    Conserved Domains (1) summary
    cd07509
    Location:8255
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
  4. XM_006722557.2XP_006722620.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006722620.1

    UniProtKB/Swiss-Prot
    Q9H0R4
    Conserved Domains (1) summary
    cl21460
    Location:1165
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  5. XM_005258371.4XP_005258428.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cd07509
    Location:8225
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
  6. XM_024451272.1XP_024307040.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X2

    Related
    ENSP00000468067.1, ENST00000590815.5
    Conserved Domains (1) summary
    cd07509
    Location:8225
    HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
  7. XM_017026040.1XP_016881529.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X4

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