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KATNAL1 katanin catalytic subunit A1 like 1 [ Homo sapiens (human) ]

Gene ID: 84056, updated on 25-Nov-2021

Summary

Official Symbol
KATNAL1provided by HGNC
Official Full Name
katanin catalytic subunit A1 like 1provided by HGNC
Primary source
HGNC:HGNC:28361
See related
Ensembl:ENSG00000102781 MIM:614764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 4.9), brain (RPKM 4.4) and 24 other tissues See more
Orthologs
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Genomic context

See KATNAL1 in Genome Data Viewer
Location:
13q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (30200026..30307551, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (30776767..30881688, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 365 Neighboring gene long intergenic non-protein coding RNA 384 Neighboring gene long intergenic non-protein coding RNA 385 Neighboring gene uncharacterized LOC102723381 Neighboring gene RNA, U6 small nuclear 64, pseudogene Neighboring gene peroxiredoxin 2 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 426 Neighboring gene long intergenic non-protein coding RNA 1058

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
GeneReviews: Not available
Genetically distinct subsets within ANCA-associated vasculitis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2599

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule-severing ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule severing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule severing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
katanin p60 ATPase-containing subunit A-like 1
Names
katanin catalytic subunit A like 1
katanin p60 subunit A like 1
p60 katanin-like 1
NP_001014402.1
NP_115492.1
XP_005266631.1
XP_016876280.1
XP_016876281.1
XP_016876282.1
XP_024305191.1
XP_024305192.1
XP_024305193.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014380.3NP_001014402.1  katanin p60 ATPase-containing subunit A-like 1

    See identical proteins and their annotated locations for NP_001014402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK097423, AL356750, BC000612
    Consensus CDS
    CCDS31956.1
    UniProtKB/Swiss-Prot
    Q9BW62
    UniProtKB/TrEMBL
    A0A024RDP8, B3KUK7
    Related
    ENSP00000369991.3, ENST00000380617.7
    Conserved Domains (1) summary
    COG0464
    Location:188483
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. NM_032116.5NP_115492.1  katanin p60 ATPase-containing subunit A-like 1

    See identical proteins and their annotated locations for NP_115492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL356750, BC000612, DR006891
    Consensus CDS
    CCDS31956.1
    UniProtKB/Swiss-Prot
    Q9BW62
    UniProtKB/TrEMBL
    A0A024RDP8
    Related
    ENSP00000369989.3, ENST00000380615.8
    Conserved Domains (1) summary
    COG0464
    Location:188483
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    30200026..30307551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020791.2XP_016876280.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:20315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. XM_024449425.1XP_024305193.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:20315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  3. XM_017020792.2XP_016876281.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:20315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  4. XM_017020793.2XP_016876282.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:20315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  5. XM_005266574.3XP_005266631.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    See identical proteins and their annotated locations for XP_005266631.1

    UniProtKB/Swiss-Prot
    Q9BW62
    UniProtKB/TrEMBL
    A0A024RDP8
    Conserved Domains (1) summary
    COG0464
    Location:188483
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  6. XM_024449424.1XP_024305192.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    Conserved Domains (1) summary
    COG0464
    Location:188483
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  7. XM_024449423.1XP_024305191.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

    Conserved Domains (1) summary
    COG0464
    Location:188483
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
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