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Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84050, updated on 23-Jun-2022

Summary

Official Symbol
Enpp2provided by RGD
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 2provided by RGD
Primary source
RGD:69298
See related
Ensembl:ENSRNOG00000004089 AllianceGenome:RGD:69298
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables lysophospholipase activity; metal ion binding activity; and phosphoric diester hydrolase activity. Involved in several processes, including cellular response to estradiol stimulus; estrous cycle; and regulation of cell-substrate adhesion. Located in Golgi apparatus and extracellular space. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 623.6), Liver (RPKM 311.4) and 9 other tissues See more
Orthologs
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Genomic context

See Enpp2 in Genome Data Viewer
Location:
7q32
Exon count:
28
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86202345..86325050, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (94479931..94563086, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 95 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093657 Neighboring gene TATA-box binding protein associated factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC93258

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alkylglycerophosphoethanolamine phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alkylglycerophosphoethanolamine phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkylglycerophosphoethanolamine phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables dinucleotide phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphodiesterase I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphodiesterase I activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphodiesterase I activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in estrous cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to polycyclic arene IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sphingolipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingolipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Names
E-NPP 2
autotaxin
extracellular lysophospholipase D
lysoPLD
phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)
NP_476445.2
XP_038935900.1
XP_038935901.1
XP_038935902.1
XP_038935903.1
XP_038935904.1
XP_038935905.1
XP_038935906.1
XP_038935907.1
XP_038935908.1
XP_038935909.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057104.3NP_476445.2  ectonucleotide pyrophosphatase/phosphodiesterase family member 2

    See identical proteins and their annotated locations for NP_476445.2

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000185
    UniProtKB/Swiss-Prot
    Q64610
    Conserved Domains (4) summary
    smart00201
    Location:5697
    SO; Somatomedin B -like domains
    smart00477
    Location:614844
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:165477
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:163517
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    86202345..86325050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079973.1XP_038935901.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X2

    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:748978
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226590
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  2. XM_039079972.1XP_038935900.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1

    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:752982
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226590
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  3. XM_039079975.1XP_038935903.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X4

    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:723953
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226590
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  4. XM_039079974.1XP_038935902.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3

    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:727957
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226590
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  5. XM_039079978.1XP_038935906.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X7

    Related
    ENSRNOP00000005561.7, ENSRNOT00000005561.7
    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:675905
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226538
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  6. XM_039079976.1XP_038935904.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X5

    Conserved Domains (3) summary
    smart00201
    Location:117158
    SO; Somatomedin B -like domains
    smart00477
    Location:700930
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:226538
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  7. XM_039079977.1XP_038935905.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X6

    Conserved Domains (3) summary
    smart00201
    Location:5697
    SO; Somatomedin B -like domains
    smart00477
    Location:691921
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:165529
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  8. XM_039079980.1XP_038935908.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X9

    Conserved Domains (3) summary
    smart00201
    Location:5697
    SO; Somatomedin B -like domains
    smart00477
    Location:662892
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:165529
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  9. XM_039079979.1XP_038935907.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X8

    Related
    ENSRNOP00000090400.1, ENSRNOT00000118544.1
    Conserved Domains (3) summary
    smart00201
    Location:5697
    SO; Somatomedin B -like domains
    smart00477
    Location:666896
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:165529
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  10. XM_039079981.1XP_038935909.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X10

    Related
    ENSRNOP00000076476.1, ENSRNOT00000101657.1
    Conserved Domains (3) summary
    smart00201
    Location:5697
    SO; Somatomedin B -like domains
    smart00477
    Location:639869
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:165477
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase