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Grip1 glutamate receptor interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84016, updated on 23-Jun-2022

Summary

Official Symbol
Grip1provided by RGD
Official Full Name
glutamate receptor interacting protein 1provided by RGD
Primary source
RGD:621667
See related
Ensembl:ENSRNOG00000004013 AllianceGenome:RGD:621667
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables signaling receptor binding activity. Involved in dendrite arborization; positive regulation of neuron projection arborization; and protein transport. Located in neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 48.3), Testes (RPKM 36.7) and 3 other tissues See more
Orthologs
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Genomic context

See Grip1 in Genome Data Viewer
Location:
7q22
Exon count:
31
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (54934856..55592274)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (64672723..64854939)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase subunit Neighboring gene uncharacterized LOC120093612 Neighboring gene uncharacterized LOC120093803 Neighboring gene uncharacterized LOC120093802 Neighboring gene DNA helicase B Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene transmembrane BAX inhibitor motif containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cellular anatomical entity IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in spine synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor-interacting protein 1
Names
AMPA receptor-interacting protein GRIP1
GRIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032069.1NP_114458.1  glutamate receptor-interacting protein 1

    See identical proteins and their annotated locations for NP_114458.1

    Status: PROVISIONAL

    Source sequence(s)
    U88572
    UniProtKB/Swiss-Prot
    P97879
    Related
    ENSRNOP00000073984.2, ENSRNOT00000088861.2
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    54934856..55592274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079960.1XP_038935888.1  glutamate receptor-interacting protein 1 isoform X3

    Related
    ENSRNOP00000076991.1, ENSRNOT00000116059.1
    Conserved Domains (1) summary
    cd00992
    Location:153236
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_039079965.1XP_038935893.1  glutamate receptor-interacting protein 1 isoform X8

    Related
    ENSRNOP00000089072.1, ENSRNOT00000103170.1
    Conserved Domains (1) summary
    cd00992
    Location:126209
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_039079962.1XP_038935890.1  glutamate receptor-interacting protein 1 isoform X5

    Conserved Domains (1) summary
    cd00992
    Location:151234
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_039079963.1XP_038935891.1  glutamate receptor-interacting protein 1 isoform X6

    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_039079961.1XP_038935889.1  glutamate receptor-interacting protein 1 isoform X4

    Related
    ENSRNOP00000091086.1, ENSRNOT00000107252.1
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_039079966.1XP_038935894.1  glutamate receptor-interacting protein 1 isoform X9

    Conserved Domains (1) summary
    cd00992
    Location:125208
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_039079958.1XP_038935886.1  glutamate receptor-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:196279
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_039079959.1XP_038935887.1  glutamate receptor-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:196279
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_039079964.1XP_038935892.1  glutamate receptor-interacting protein 1 isoform X7

    Conserved Domains (1) summary
    cd00992
    Location:196279
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_039079967.1XP_038935895.1  glutamate receptor-interacting protein 1 isoform X10

    Conserved Domains (1) summary
    cd00992
    Location:254335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_039079969.1XP_038935897.1  glutamate receptor-interacting protein 1 isoform X12

    Related
    ENSRNOP00000005545.3, ENSRNOT00000005545.6
    Conserved Domains (1) summary
    cd00992
    Location:254335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_039079968.1XP_038935896.1  glutamate receptor-interacting protein 1 isoform X11

    Conserved Domains (1) summary
    cd00992
    Location:254335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_039079970.1XP_038935898.1  glutamate receptor-interacting protein 1 isoform X13

    Conserved Domains (1) summary
    cd00992
    Location:147228
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_005486730.1 RNA Sequence