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MYC2 Basic helix-loop-helix (bHLH) DNA-binding family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840158, updated on 8-Jul-2021

Summary

Gene symbol
MYC2
Gene description
Basic helix-loop-helix (bHLH) DNA-binding family protein
Primary source
Araport:AT1G32640
Locus tag
AT1G32640
Gene type
protein coding
RNA name
Basic helix-loop-helix (bHLH) DNA-binding family protein
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMYC2; F6N18.4; F6N18_4; JAI1; JASMONATE INSENSITIVE 1; JIN1; RD22BP1; ZBF1
Summary
Encodes a MYC-related transcriptional activator with a typical DNA binding domain of a basic helix-loop-helix leucine zipper motif. Binds to an extended G-Box promoter motif and interacts with Jasmonate ZIM-domain proteins. Its transcription is induced by dehydration stress and ABA treatment. Negative regulator of blue light#Aeimediated photomorphogenic growth and blue and far-red-light#Aeiregulated gene expression. Positive regulator of lateral root formation. Regulates diverse JA-dependent functions. Negatively regulates Trp metabolism and biosynthesis of Trp-derived secondary metabolites. Positively regulates flavonoid biosynthesis, resistance to insects, and response to oxidative stress. Regulates other transcription factors, and negatively regulates its own expression.
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Genomic context

See MYC2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_003070.9 (11798119..11801407, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene tRNA Neighboring gene FAM50A-like protein Neighboring gene hypothetical protein Neighboring gene F-box and associated interaction domains-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

NM_102998.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular ATP signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect indole glucosinolate biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_negative_effect indole glucosinolate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of defense response to insect IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of tryptophan metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to desiccation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to jasmonic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to wounding TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within stomatal complex development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_negative_effect tryptophan metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
Basic helix-loop-helix (bHLH) DNA-binding family protein
NP_174541.1
  • MYC2; FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 13 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: Basic helix-loop-helix (bHLH) DNA-binding family protein (TAIR:AT4G17880.1); Has 4078 Blast hits to 3762 proteins in 672 species: Archae - 2; Bacteria - 2; Metazoa - 761; Fungi - 108; Plants - 3150; Viruses - 25; Other Eukaryotes - 30 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    11798119..11801407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102998.4NP_174541.1  Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174541.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39204
    UniProtKB/TrEMBL
    A0A178W7C3
    Conserved Domains (2) summary
    cd11449
    Location:445521
    bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins
    pfam14215
    Location:68252
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
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