RCD1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: RCD1
Gene description: WWE protein-protein interaction domain protein family
Primary source: Araport:AT1G32230
Locus tag: AT1G32230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA P8 (INTERACTING PROTEIN); ATP8; AtRCD1; CEO; CEO1; F3C3.1; F3C3_1; RADICAL-INDUCED CELL DEATH1; REDOX IMBALANCED 1; RIMB1
Summary: Encodes a protein belonging to the (ADP-ribosyl)transferase domain-containing subfamily of WWE protein-protein interaction domain protein family. Superoxide radicals are necessary and sufficient to propagate cell death or lesion formation in rcd1 mutants. Without stress treatment, RCD1 is localized in the nucleus. Under high salt or oxidative stress, RCD1 is found not only in the nucleus but also in the cytoplasm.
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Genomic context

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Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (11611891..11617419)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Sm core protein SmEb regulates salt stress responses through maintaining proper splicing of RCD1 pre-mRNA in Arabidopsis.
Title: The Sm core protein SmEb regulates salt stress responses through maintaining proper splicing of RCD1 pre-mRNA in Arabidopsis.
alphaalpha-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes.
Title: αα-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes.
Flanking Disorder of the Folded alphaalpha-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution.
Title: Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution.
Dissecting the interaction of photosynthetic electron transfer with mitochondrial signalling and hypoxic response in the Arabidopsis rcd1 mutant.
Title: Dissecting the interaction of photosynthetic electron transfer with mitochondrial signalling and hypoxic response in the Arabidopsis rcd1 mutant.
SRO1 has partially overlapping functions with RCD1 in plant response to HgCl2 and H2O2 stress. Analysis of the transcriptional expression of SROs indicated that both of the RCD1 and SRO1 transcripts were up-regulated by HgCl2 and light, not by other stresses, and that of SRO5 was induced by salt
Title: Arabidopsis SIMILAR TO RCD-ONE genes are ubiquitous and respond to multiple abiotic stresses through diverse signaling pathways.
RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III.
Title: Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors.
Arabidopsis downy mildew pathogen targets RCD1 to prevent activation of plant immunity.
Title: Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1.
Study determine the structure of RCD1-RST domain, a unique folded hub illuminating details of its interactions with disordered partners of its stress-associated interactome. Similar structures are identified in the PAH, TAFH, and NCBD domains. These alphaalpha hubs, as they share an aa-hairpin super-secondary motif, which serves as an organizing platform for malleable helices of varying topology.
Title: Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common αα-Scaffold for Disorder in Transcriptional Networks.
The maize SRO1b protein is encoded by 595 amino acid residues and shared conserved protein structures with Arabidopsis RCD1 and SRO1 proteins.
Title: Maize similar to RCD1 gene induced by salt enhances Arabidopsis thaliana abiotic stress resistance.
NMR spectroscopy further demonstrated that DREB2A underwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, whereas peptides from ANAC013 and ANAC046 formed different structures or were fuzzy in the complexes.
Title: Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001160916.1

Supported by ESTs:

NM_001332998.1

Supported by ESTs:

NM_001332999.1

Supported by ESTs:

NM_001333000.1

Supported by ESTs:

NM_102956.3

Supported by ESTs:

NM_179408.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ethylene-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ozone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: WWE protein-protein interaction domain protein family

NP_001154388.1

WWE protein-protein interaction domain protein family; CONTAINS InterPro DOMAIN/s: WWE domain (InterPro:IPR004170), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), RST domain of plant C-terminal (InterPro:IPR022003); BEST Arabidopsis thaliana protein match is: similar to RCD one 1 (TAIR:AT2G35510.1); Has 178 Blast hits to 176 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 7; Fungi - 0; Plants - 167; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NP_564391.1

RADICAL-INDUCED CELL DEATH1 (RCD1); CONTAINS InterPro DOMAIN/s: WWE domain (InterPro:IPR004170), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), RST domain of plant C-terminal (InterPro:IPR022003); BEST Arabidopsis thaliana protein match is: similar to RCD one 1 (TAIR:AT2G35510.1); Has 179 Blast hits to 178 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 7; Fungi - 0; Plants - 168; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NP_849739.1

RADICAL-INDUCED CELL DEATH1 (RCD1); CONTAINS InterPro DOMAIN/s: WWE domain (InterPro:IPR004170), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), RST domain of plant C-terminal (InterPro:IPR022003); BEST Arabidopsis thaliana protein match is: similar to RCD one 1 (TAIR:AT2G35510.1); Has 178 Blast hits to 176 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 7; Fungi - 0; Plants - 167; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11611891..11617419

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179408.3 → NP_849739.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849739.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIM2

Conserved Domains (3) summary

pfam00644
Location:320 → 449

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12174
Location:501 → 566

RST; RCD1-SRO-TAF4 (RST) plant domain

cl00283
Location:360 → 405

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001332998.1 → NP_001320331.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIM2
NM_001332999.1 → NP_001320332.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIM2
NM_001333000.1 → NP_001320330.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIM2
NM_102956.3 → NP_564391.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564391.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RY59, Q93YR6, Q94KU0, Q9FT85, Q9FVR7

UniProtKB/TrEMBL

M5BED9, M5BEK5, M5BEP5, M5BEP7, M5BF30, M5BF31, M5BFC3, M5BFC4

Conserved Domains (3) summary

pfam00644
Location:320 → 449

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12174
Location:502 → 567

RST; RCD1-SRO-TAF4 (RST) plant domain

cl00283
Location:360 → 405

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001160916.1 → NP_001154388.1 WWE protein-protein interaction domain protein family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154388.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIM2, F4ICM3, M5BEK5

Conserved Domains (3) summary

pfam00644
Location:320 → 449

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12174
Location:501 → 566

RST; RCD1-SRO-TAF4 (RST) plant domain

cl00283
Location:360 → 405

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...