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B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 84002, updated on 22-Sep-2022

Summary

Official Symbol
B3GNT5provided by HGNC
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:15684
See related
Ensembl:ENSG00000176597 MIM:615333; AllianceGenome:HGNC:15684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3GN-T5; beta3Gn-T5
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 17.8), small intestine (RPKM 13.8) and 20 other tissues See more
Orthologs
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Genomic context

See B3GNT5 in Genome Data Viewer
Location:
3q27.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183253253..183273385)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186060144..186080277)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182971041..182991173)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 3 pseudogene 4 Neighboring gene MCF.2 cell line derived transforming sequence-like 2 Neighboring gene uncharacterized LOC124906310 Neighboring gene RNA, 5S ribosomal pseudogene 151 Neighboring gene uncharacterized LOC107986160 Neighboring gene Sharpr-MPRA regulatory region 12547

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

General protein information

Preferred Names
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Names
BGnT-5
UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5
beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase
beta-1,3-Gn-T5
beta-1,3-N-acetylglucosaminyltransferase 5
beta-1,3-N-acetylglucosaminyltransferase bGnT-5
lactotriaosylceramide synthase
lc(3)Cer synthase
lc3 synthase
NP_114436.1
XP_005247880.1
XP_011511529.1
XP_011511530.1
XP_047305013.1
XP_047305014.1
XP_047305015.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032047.5NP_114436.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

    See identical proteins and their annotated locations for NP_114436.1

    Status: REVIEWED

    Source sequence(s)
    AK074235, AK074424, BP270576
    Consensus CDS
    CCDS3244.1
    UniProtKB/Swiss-Prot
    Q8WWP9, Q9BYG0
    Related
    ENSP00000316173.3, ENST00000326505.4
    Conserved Domains (1) summary
    cl21608
    Location:102299
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    183253253..183273385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513228.3XP_011511530.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011511530.1

    UniProtKB/Swiss-Prot
    Q8WWP9, Q9BYG0
    Conserved Domains (1) summary
    cl21608
    Location:102299
    Galactosyl_T; Galactosyltransferase
  2. XM_047449057.1XP_047305013.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q8WWP9
  3. XM_011513227.3XP_011511529.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011511529.1

    UniProtKB/Swiss-Prot
    Q8WWP9, Q9BYG0
    Conserved Domains (1) summary
    cl21608
    Location:102299
    Galactosyl_T; Galactosyltransferase
  4. XM_047449058.1XP_047305014.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q8WWP9
  5. XM_047449059.1XP_047305015.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q8WWP9
  6. XM_005247823.6XP_005247880.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005247880.1

    UniProtKB/Swiss-Prot
    Q8WWP9, Q9BYG0
    Related
    ENSP00000420778.1, ENST00000460419.1
    Conserved Domains (1) summary
    cl21608
    Location:102299
    Galactosyl_T; Galactosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186060144..186080277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)