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REG4 regenerating family member 4 [ Homo sapiens (human) ]

Gene ID: 83998, updated on 11-Jul-2021

Summary

Official Symbol
REG4provided by HGNC
Official Full Name
regenerating family member 4provided by HGNC
Primary source
HGNC:HGNC:22977
See related
Ensembl:ENSG00000134193 MIM:609846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GISP; RELP; REG-IV
Expression
Biased expression in small intestine (RPKM 174.4), colon (RPKM 137.8) and 2 other tissues See more
Orthologs
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Genomic context

See REG4 in Genome Data Viewer
Location:
1p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (119794017..119811460, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120336640..120354083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC105378936 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 2 Neighboring gene uncharacterized LOC105378938 Neighboring gene NBPF member 7, pseudogene Neighboring gene profilin 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mannan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regenerating islet-derived protein 4
Names
REG-4
REG-like protein
gastrointestinal secretory protein
reg IV
regenerating gene type IV
regenerating islet-derived family, member 4
regenerating islet-derived protein IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159352.2NP_001152824.1  regenerating islet-derived protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001152824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL359752, AY126670
    Consensus CDS
    CCDS906.1
    UniProtKB/Swiss-Prot
    Q9BYZ8
    UniProtKB/TrEMBL
    A0A024R0M1
    Related
    ENSP00000346158.1, ENST00000354219.5
    Conserved Domains (1) summary
    cd03594
    Location:30156
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  2. NM_001159353.2NP_001152825.1  regenerating islet-derived protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001152825.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons but has an alternate 3' end, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL359752, AY126672
    Consensus CDS
    CCDS53354.1
    UniProtKB/Swiss-Prot
    Q9BYZ8
    Related
    ENSP00000358409.4, ENST00000369401.4
    Conserved Domains (1) summary
    cl02432
    Location:3055
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  3. NM_032044.4NP_114433.1  regenerating islet-derived protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_114433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL359752, AY007243, AY126670
    Consensus CDS
    CCDS906.1
    UniProtKB/Swiss-Prot
    Q9BYZ8
    UniProtKB/TrEMBL
    A0A024R0M1
    Related
    ENSP00000256585.5, ENST00000256585.10
    Conserved Domains (1) summary
    cd03594
    Location:30156
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    119794017..119811460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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