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PLA2G10 phospholipase A2 group X [ Homo sapiens (human) ]

Gene ID: 8399, updated on 12-Aug-2018

Summary

Official Symbol
PLA2G10provided by HGNC
Official Full Name
phospholipase A2 group Xprovided by HGNC
Primary source
HGNC:HGNC:9029
See related
Ensembl:ENSG00000069764 MIM:603603; Vega:OTTHUMG00000048069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPLA2; GXPLA2; GXSPLA2; sPLA2-X
Summary
This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
Expression
Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues See more
Orthologs

Genomic context

See PLA2G10 in Genome Data Viewer
Location:
16p13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (14672548..14694662, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14766405..14788526, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene poly(A)-specific ribonuclease Neighboring gene RNA, 7SL, cytoplasmic 274, pseudogene Neighboring gene RNA, U7 small nuclear 125 pseudogene Neighboring gene bifunctional apoptosis regulator Neighboring gene collagen alpha-3(IX) chain-like Neighboring gene group 10 secretory phospholipase A2-like Neighboring gene nuclear pore complex interacting protein family member A3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env sPLA(2)-X neutralizes human immunodeficiency virus type 1 (HIV-1) through degradation of the viral membrane (gp120) and inhibits the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4(+) T cells PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119918, MGC119919, MGC133367

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to leukemia inhibitory factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lysophospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysophospholipid transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of arachidonic acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of arachidonic acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cellular protein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
positive regulation of prostaglandin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
group 10 secretory phospholipase A2
Names
group X secretory phospholipase A2
phosphatidylcholine 2-acylhydrolase 10
NP_003552.1
XP_011520997.1
XP_011520998.1
XP_011520999.1
XP_011521000.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003561.2NP_003552.1  group 10 secretory phospholipase A2 preproprotein

    See identical proteins and their annotated locations for NP_003552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    U95301
    Consensus CDS
    CCDS10555.1
    UniProtKB/Swiss-Prot
    O15496
    Related
    ENSP00000393847.3, OTTHUMP00000045725, ENST00000438167.7, OTTHUMT00000109393
    Conserved Domains (1) summary
    cd00125
    Location:43157
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RNA

  1. NR_133651.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BM739473, U95301

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    14672548..14694662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522697.2XP_011520999.1  group 10 secretory phospholipase A2 isoform X3

    See identical proteins and their annotated locations for XP_011520999.1

    Related
    ENSP00000456433.1, OTTHUMP00000250190, ENST00000567462.1
    Conserved Domains (1) summary
    cd00125
    Location:43119
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. XM_011522695.3XP_011520997.1  group 10 secretory phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_011520997.1

    Conserved Domains (1) summary
    cd00125
    Location:43122
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. XM_011522696.3XP_011520998.1  group 10 secretory phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011520998.1

    Conserved Domains (1) summary
    cd00125
    Location:43118
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  4. XM_011522698.2XP_011521000.1  group 10 secretory phospholipase A2 isoform X4

    See identical proteins and their annotated locations for XP_011521000.1

    Conserved Domains (1) summary
    cd00125
    Location:43119
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    245407..267435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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