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IFI27L2 interferon alpha inducible protein 27 like 2 [ Homo sapiens (human) ]

Gene ID: 83982, updated on 7-Apr-2025

Summary

Official Symbol
IFI27L2provided by HGNC
Official Full Name
interferon alpha inducible protein 27 like 2provided by HGNC
Primary source
HGNC:HGNC:19753
See related
Ensembl:ENSG00000119632 MIM:611319; AllianceGenome:HGNC:19753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLH29; FAM14A; ISG12B
Summary
Predicted to enable molecular adaptor activity. Involved in apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in adrenal (RPKM 32.8), brain (RPKM 28.7) and 25 other tissues See more
Orthologs
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Genomic context

See IFI27L2 in Genome Data Viewer
Location:
14q32.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94127781..94129604, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88355089..88356912, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94594118..94595941, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:94576419-94577618 Neighboring gene interferon alpha inducible protein 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94605193-94605692 Neighboring gene uncharacterized LOC105370634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94639893-94640455 Neighboring gene protein phosphatase 4 regulatory subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Pathways from PubChem

General gene information

Clone Names

  • MGC44913

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interferon alpha-inducible protein 27-like protein 2
Names
ISG12(b) protein
family with sequence similarity 14, member A
interferon-stimulated gene 12b protein
pIFI27-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032036.3NP_114425.1  interferon alpha-inducible protein 27-like protein 2 precursor

    See identical proteins and their annotated locations for NP_114425.1

    Status: VALIDATED

    Source sequence(s)
    BC032626, BE737110
    Consensus CDS
    CCDS9920.1
    UniProtKB/Swiss-Prot
    Q8TBD7, Q9H2X8, Q9NYL0
    Related
    ENSP00000238609.3, ENST00000238609.4
    Conserved Domains (1) summary
    pfam06140
    Location:2088
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    94127781..94129604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1242343..1244166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    88355089..88356912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)