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Jam3 junction adhesion molecule 3 [ Mus musculus (house mouse) ]

Gene ID: 83964, updated on 8-Feb-2024

Summary

Official Symbol
Jam3provided by MGI
Official Full Name
junction adhesion molecule 3provided by MGI
Primary source
MGI:MGI:1933825
See related
Ensembl:ENSMUSG00000031990 AllianceGenome:MGI:1933825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JAM-3; JAM-C; Jcam3; 1110002N23Rik
Summary
Enables identical protein binding activity and integrin binding activity. Involved in angiogenesis; cell-cell adhesion; and hematopoietic stem cell migration to bone marrow. Acts upstream of or within several processes, including leukocyte migration involved in inflammatory response; myeloid progenitor cell differentiation; and regulation of actin cytoskeleton organization by cell-cell adhesion. Located in Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 37.0), limb E14.5 (RPKM 30.4) and 21 other tissues See more
Orthologs
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Genomic context

See Jam3 in Genome Data Viewer
Location:
9 A4; 9 12.27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (27008680..27066739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (27097384..27155421, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8283 Neighboring gene STARR-positive B cell enhancer ABC_E3819 Neighboring gene thymocyte nuclear protein 1 Neighboring gene VPS26 retromer complex component B Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene STARR-seq mESC enhancer starr_23617 Neighboring gene STARR-seq mESC enhancer starr_23618 Neighboring gene predicted gene, 57534 Neighboring gene predicted gene, 53501 Neighboring gene STARR-positive B cell enhancer mm9_chr9:27020677-27020977 Neighboring gene STARR-seq mESC enhancer starr_23621 Neighboring gene immunoglobulin superfamily, member 9B Neighboring gene STARR-seq mESC enhancer starr_23623

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apical protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in granulocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell migration to bone marrow IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell migration to bone marrow ISO
Inferred from Sequence Orthology
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of actin cytoskeleton organization by cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in paranodal junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein complex involved in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
junctional adhesion molecule C
Names
junction cell adhesion molecule 3
junction cell adhesion molecule C
junctional adhesion molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023277.4NP_075766.1  junctional adhesion molecule C precursor

    See identical proteins and their annotated locations for NP_075766.1

    Status: VALIDATED

    Source sequence(s)
    AI850297, AK013156, AW106511
    Consensus CDS
    CCDS22939.1
    UniProtKB/Swiss-Prot
    Q8BT59, Q9D1M9, Q9D8B7, Q9EPK4
    Related
    ENSMUSP00000034472.9, ENSMUST00000034472.16
    Conserved Domains (3) summary
    cd00096
    Location:156231
    Ig; Immunoglobulin domain
    pfam07679
    Location:39135
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:37118
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    27008680..27066739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244741.2XP_030100601.1  junctional adhesion molecule C isoform X1

    Conserved Domains (2) summary
    smart00409
    Location:20108
    IG; Immunoglobulin
    pfam13927
    Location:115196
    Ig_3; Immunoglobulin domain
  2. XM_036155416.1XP_036011309.1  junctional adhesion molecule C isoform X2

    Conserved Domains (2) summary
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cl11960
    Location:33136
    Ig; Immunoglobulin domain