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AT1G02305 Cysteine proteinases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839538, updated on 15-Oct-2023

Summary

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Gene symbol
AT1G02305
Gene description
Cysteine proteinases superfamily protein
Primary source
Araport:AT1G02305
Locus tag
AT1G02305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Genomic context

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Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (455688..458164)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cysteine proteinases superfamily protein Neighboring gene ncRNA Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene integrator complex subunit-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities. Porodko A, et al. Biol Chem, 2018 Sep 25. PMID 29924726
  2. Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis. Ge Y, et al. Cell Death Differ, 2016 Sep 1. PMID 27058316, Free PMC Article
  3. Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis. Cai YM, et al. New Phytol, 2018 May. PMID 28675441, Free PMC Article
  4. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endoplasmic reticulum-stress-induced programmed cell death is regulated positively by cathepsin B and negatively by PBA1, revealing a complex picture behind caspase-3-like activity in plants. Cathepsin B may execute its function after tonoplast rupture and works in parallel with VPE.[cathepsin B2]
    Title: Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis.
  2. AtCathB2 and AtCathB3 are two closely related PLCPs which display subtle differences in their hydrolytic properties and substrate specificities. Both enzymes can act as endopeptidases and carboxydipeptidases.[CathB2]
    Title: The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_100111.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 

General protein information

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Preferred Names
Cysteine proteinases superfamily protein
NP_563648.1
  • Cysteine proteinases superfamily protein; FUNCTIONS IN: cysteine-type endopeptidase activity, cysteine-type peptidase activity; INVOLVED IN: proteolysis, regulation of catalytic activity; LOCATED IN: vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Peptidase C1A, cathepsin B (InterPro:IPR015643), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Peptidase C1A, propeptide (InterPro:IPR012599); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT1G02300.1); Has 7484 Blast hits to 7435 proteins in 695 species: Archae - 51; Bacteria - 161; Metazoa - 3268; Fungi - 4; Plants - 1732; Viruses - 146; Other Eukaryotes - 2122 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    455688..458164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100111.3 → NP_563648.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563648.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHV8, Q93VC9
    UniProtKB/TrEMBL
    A0A178WH58, A0A5S9S6F5
    Conserved Domains (2) summary
    cd02620
    Location:107 → 340
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam08127
    Location:46 → 88
    Propeptide_C1; Peptidase family C1 propeptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93VC9.1

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