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TATDN1 TatD DNase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 83940, updated on 12-Jun-2021

Summary

Official Symbol
TATDN1provided by HGNC
Official Full Name
TatD DNase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24220
See related
Ensembl:ENSG00000147687 MIM:619364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA11
Expression
Ubiquitous expression in thyroid (RPKM 16.0), ovary (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See TATDN1 in Genome Data Viewer
Location:
8q24.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (124488494..124540486, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125500735..125551329, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNF139 divergent transcript Neighboring gene tRNA methyltransferase 12 homolog Neighboring gene ring finger protein 139 Neighboring gene microRNA 6844 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene uncharacterized LOC105375741

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TatD DNase domain containing 1 (TATDN1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
putative deoxyribonuclease TATDN1
Names
hepatocarcinoma high expression protein
NP_001139632.1
NP_001304818.1
NP_001304819.1
NP_001304820.1
NP_114415.1
XP_006716729.1
XP_006716730.1
XP_006716731.1
XP_006716732.1
XP_006716733.1
XP_006716734.1
XP_011515633.1
XP_016869384.1
XP_016869385.1
XP_016869386.1
XP_016869387.1
XP_016869388.1
XP_024303061.1
XP_024303062.1
XP_024303063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146160.1NP_001139632.1  putative deoxyribonuclease TATDN1 isoform b

    See identical proteins and their annotated locations for NP_001139632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (b) that is shorter than isoform c.
    Source sequence(s)
    AF212250, AV729364, AY071865, BC007066
    Consensus CDS
    CCDS55273.1
    UniProtKB/Swiss-Prot
    Q6P1N9
    Related
    ENSP00000428336.1, ENST00000519548.5
    Conserved Domains (1) summary
    cd01310
    Location:1247
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  2. NM_001317889.1NP_001304818.1  putative deoxyribonuclease TATDN1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AV729364, BC007066, BU784642, BX332564
    Related
    ENSP00000430274.1, ENST00000522810.5
    Conserved Domains (1) summary
    cd01310
    Location:6330
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  3. NM_001317890.1NP_001304819.1  putative deoxyribonuclease TATDN1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (d) that is shorter than isoform c.
    Source sequence(s)
    AV729364, AY071865, BC007066, BG532054
    Consensus CDS
    CCDS83323.1
    UniProtKB/Swiss-Prot
    Q6P1N9
    UniProtKB/TrEMBL
    A0A0D9SGD3
    Related
    ENSP00000487380.1, ENST00000630259.1
    Conserved Domains (1) summary
    cd01310
    Location:14240
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  4. NM_001317891.1NP_001304820.1  putative deoxyribonuclease TATDN1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (e) that is shorter than isoform c.
    Source sequence(s)
    AV729364, AY071865, BC007066, BG529611
    UniProtKB/Swiss-Prot
    Q6P1N9
    Conserved Domains (1) summary
    cl00281
    Location:1149
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  5. NM_032026.4NP_114415.1  putative deoxyribonuclease TATDN1 isoform a

    See identical proteins and their annotated locations for NP_114415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region compared to variant 4. The encoded isoform (a) is shorter than isoform c.
    Source sequence(s)
    AF212250, AV729364, BC007066, BC064964
    Consensus CDS
    CCDS6351.1
    UniProtKB/Swiss-Prot
    Q6P1N9
    Related
    ENSP00000276692.6, ENST00000276692.11
    Conserved Domains (1) summary
    cd01310
    Location:6294
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RNA

  1. NR_027427.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon compared to variant 4. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090198, AF212250, AV729364, BC007066
    Related
    ENST00000523214.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    124488494..124540486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447293.1XP_024303061.1  putative deoxyribonuclease TATDN1 isoform X6

    Conserved Domains (1) summary
    cd01310
    Location:5272
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  2. XM_017013898.2XP_016869387.1  putative deoxyribonuclease TATDN1 isoform X8

    UniProtKB/Swiss-Prot
    Q6P1N9
    Conserved Domains (1) summary
    cd01310
    Location:1247
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  3. XM_017013896.2XP_016869385.1  putative deoxyribonuclease TATDN1 isoform X7

    Conserved Domains (1) summary
    cd01310
    Location:21261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  4. XM_006716667.3XP_006716730.1  putative deoxyribonuclease TATDN1 isoform X3

    See identical proteins and their annotated locations for XP_006716730.1

    Conserved Domains (1) summary
    cd01310
    Location:21297
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  5. XM_017013897.2XP_016869386.1  putative deoxyribonuclease TATDN1 isoform X7

    Conserved Domains (1) summary
    cd01310
    Location:21261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  6. XM_011517331.3XP_011515633.1  putative deoxyribonuclease TATDN1 isoform X2

    Conserved Domains (1) summary
    cd01310
    Location:5308
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  7. XM_006716671.3XP_006716734.1  putative deoxyribonuclease TATDN1 isoform X7

    Conserved Domains (1) summary
    cd01310
    Location:21261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  8. XM_006716670.3XP_006716733.1  putative deoxyribonuclease TATDN1 isoform X4

    Conserved Domains (1) summary
    cd01310
    Location:1283
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  9. XM_017013895.2XP_016869384.1  putative deoxyribonuclease TATDN1 isoform X5

  10. XM_006716666.4XP_006716729.1  putative deoxyribonuclease TATDN1 isoform X1

    Conserved Domains (1) summary
    cd01310
    Location:13314
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  11. XM_024447295.1XP_024303063.1  putative deoxyribonuclease TATDN1 isoform X8

    Conserved Domains (1) summary
    cd01310
    Location:1247
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  12. XM_006716668.3XP_006716731.1  putative deoxyribonuclease TATDN1 isoform X3

    See identical proteins and their annotated locations for XP_006716731.1

    Conserved Domains (1) summary
    cd01310
    Location:21297
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  13. XM_024447294.1XP_024303062.1  putative deoxyribonuclease TATDN1 isoform X7

    Conserved Domains (1) summary
    cd01310
    Location:21261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  14. XM_006716669.3XP_006716732.1  putative deoxyribonuclease TATDN1 isoform X3

    See identical proteins and their annotated locations for XP_006716732.1

    Conserved Domains (1) summary
    cd01310
    Location:21297
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  15. XM_017013899.1XP_016869388.1  putative deoxyribonuclease TATDN1 isoform X9

    Related
    ENSP00000476180.1, ENST00000605953.5

RNA

  1. XR_428386.4 RNA Sequence

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