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EIF2A eukaryotic translation initiation factor 2A [ Homo sapiens (human) ]

Gene ID: 83939, updated on 23-Nov-2021

Summary

Official Symbol
EIF2Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 2Aprovided by HGNC
Primary source
HGNC:HGNC:3254
See related
Ensembl:ENSG00000144895 MIM:609234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA02; EIF-2A; MST089; MSTP004; MSTP089
Summary
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Annotation information
Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018]
Expression
Ubiquitous expression in thyroid (RPKM 30.8), ovary (RPKM 23.5) and 25 other tissues See more
Orthologs
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Genomic context

See EIF2A in Genome Data Viewer
Location:
3q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (150546726..150586016)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150264574..150303803)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TSC22 domain family member 2 Neighboring gene stress associated endoplasmic reticulum protein 1 Neighboring gene selenoprotein T Neighboring gene Sin3A associated protein 30kDa pseudogene Neighboring gene Sharpr-MPRA regulatory region 4372

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat increases phosphorylation of EIF2A in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in SREBP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2A
Names
65 kDa eukaryotic translation initiation factor 2A
eukaryotic translation initiation factor 2A, 65kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319043.2NP_001305972.1  eukaryotic translation initiation factor 2A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC107426
    Consensus CDS
    CCDS82861.1
    UniProtKB/Swiss-Prot
    Q9BY44
    Related
    ENSP00000420537.1, ENST00000487799.5
    Conserved Domains (3) summary
    pfam05308
    Location:411496
    Mito_fiss_reg; Mitochondrial fission regulator
    pfam08662
    Location:191386
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:252286
    7WD40; WD40 repeat [structural motif]
  2. NM_001319044.2NP_001305973.1  eukaryotic translation initiation factor 2A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC107426
    Consensus CDS
    CCDS82859.1
    UniProtKB/Swiss-Prot
    Q9BY44
    Related
    ENSP00000385292.3, ENST00000406576.7
    Conserved Domains (3) summary
    pfam05308
    Location:375460
    Mito_fiss_reg; Mitochondrial fission regulator
    pfam08662
    Location:155350
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:4281
    7WD40; WD40 repeat [structural motif]
  3. NM_001319045.2NP_001305974.1  eukaryotic translation initiation factor 2A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in an internal exon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC107426
    Consensus CDS
    CCDS82860.1
    UniProtKB/Swiss-Prot
    Q9BY44
    UniProtKB/TrEMBL
    F8WAE5
    Related
    ENSP00000273435.5, ENST00000273435.9
    Conserved Domains (4) summary
    pfam05308
    Location:431516
    Mito_fiss_reg; Mitochondrial fission regulator
    pfam08662
    Location:211406
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:272306
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:45138
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001319046.2NP_001305975.1  eukaryotic translation initiation factor 2A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' UTR and 5' coding region and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC107426
    UniProtKB/Swiss-Prot
    Q9BY44
    Conserved Domains (2) summary
    sd00039
    Location:6397
    7WD40; WD40 repeat [structural motif]
    pfam08662
    Location:6197
    eIF2A; Eukaryotic translation initiation factor eIF2A
  5. NM_032025.5NP_114414.2  eukaryotic translation initiation factor 2A isoform 1

    See identical proteins and their annotated locations for NP_114414.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC107426
    Consensus CDS
    CCDS46935.1
    UniProtKB/Swiss-Prot
    Q9BY44
    Related
    ENSP00000417229.1, ENST00000460851.6
    Conserved Domains (3) summary
    pfam05308
    Location:436521
    Mito_fiss_reg; Mitochondrial fission regulator
    pfam08662
    Location:216411
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:277311
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    150546726..150586016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513224.2XP_011511526.1  eukaryotic translation initiation factor 2A isoform X1

    Conserved Domains (2) summary
    pfam08662
    Location:216411
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:277311
    7WD40; WD40 repeat [structural motif]
  2. XM_024453787.1XP_024309555.1  eukaryotic translation initiation factor 2A isoform X2

    Related
    ENSP00000420611.1, ENST00000465535.1
    Conserved Domains (2) summary
    pfam08662
    Location:1186
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:5286
    7WD40; WD40 repeat [structural motif]
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