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STK40 serine/threonine kinase 40 [ Homo sapiens (human) ]

Gene ID: 83931, updated on 13-Mar-2020

Summary

Official Symbol
STK40provided by HGNC
Official Full Name
serine/threonine kinase 40provided by HGNC
Primary source
HGNC:HGNC:21373
See related
Ensembl:ENSG00000196182 MIM:609437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHIK; SgK495
Expression
Ubiquitous expression in testis (RPKM 28.4), ovary (RPKM 17.2) and 25 other tissues See more
Orthologs

Genomic context

See STK40 in Genome Data Viewer
Location:
1p34.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (36339628..36385924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36805225..36851525, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene Sharpr-MPRA regulatory region 2392 Neighboring gene SH3 domain containing 21 Neighboring gene eva-1 homolog B Neighboring gene Sharpr-MPRA regulatory region 4421 Neighboring gene RNA, U4 small nuclear 27, pseudogene Neighboring gene LSM10, U7 small nuclear RNA associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with SgK495 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LSM10

Homology

Clone Names

  • MGC4796, 2310004N11Rik, RP11-268J15.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 40
Names
SINK-homologous serine/threonine-protein kinase
Ser/Thr-like kinase
sugen kinase 495
NP_001269475.1
NP_001269476.1
NP_114406.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282546.2NP_001269475.1  serine/threonine-protein kinase 40 isoform 1

    See identical proteins and their annotated locations for NP_001269475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL834137, BC008344, DA375448
    Consensus CDS
    CCDS60089.1
    UniProtKB/Swiss-Prot
    Q8N2I9
    Related
    ENSP00000362222.3, ENST00000373130.7
    Conserved Domains (1) summary
    cd13974
    Location:43335
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
  2. NM_001282547.2NP_001269476.1  serine/threonine-protein kinase 40 isoform 2

    See identical proteins and their annotated locations for NP_001269476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC007835, DA375448
    Consensus CDS
    CCDS407.1
    UniProtKB/Swiss-Prot
    Q8N2I9
    Related
    ENSP00000362224.3, ENST00000373132.3
    Conserved Domains (1) summary
    cd13974
    Location:38330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
  3. NM_032017.3NP_114406.1  serine/threonine-protein kinase 40 isoform 2

    See identical proteins and their annotated locations for NP_114406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AL834137, DA375448
    Consensus CDS
    CCDS407.1
    UniProtKB/Swiss-Prot
    Q8N2I9
    Related
    ENSP00000362221.3, ENST00000373129.7
    Conserved Domains (1) summary
    cd13974
    Location:38330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    36339628..36385924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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