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Trps1 transcriptional repressor GATA binding 1 [ Mus musculus (house mouse) ]

Gene ID: 83925, updated on 5-Jan-2022

Summary

Official Symbol
Trps1provided by MGI
Official Full Name
transcriptional repressor GATA binding 1provided by MGI
Primary source
MGI:MGI:1927616
See related
Ensembl:ENSMUSG00000038679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI115454; AI447310; D15Ertd586e
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in hair follicle development and regulation of chondrocyte differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; negative regulation of transcription, DNA-templated; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skin. Used to study trichorhinophalangeal syndrome type I. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in limb E14.5 (RPKM 5.4), bladder adult (RPKM 4.0) and 17 other tissues See more
Orthologs
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Genomic context

See Trps1 in Genome Data Viewer
Location:
15 C; 15 19.18 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (50518149..50754027, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (50654757..50890631, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (50486303..50721587, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23848 Neighboring gene G2/mitotic-specific cyclin-B1 pseudogene Neighboring gene microRNA 1907 Neighboring gene predicted gene, 48913 Neighboring gene predicted gene, 53881 Neighboring gene predicted gene, 34446

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46754, MGC107472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger transcription factor Trps1
Names
trichorhinophalangeal syndrome I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310481.1NP_001297410.1  zinc finger transcription factor Trps1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC155307, AK142355, CN667090, DV651380
    Consensus CDS
    CCDS79370.1
    UniProtKB/TrEMBL
    Q3UQJ9, V9GX74
    Related
    ENSMUSP00000139017.2, ENSMUST00000183757.8
    Conserved Domains (2) summary
    smart00401
    Location:895938
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:899955
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  2. NM_001310485.1NP_001297414.1  zinc finger transcription factor Trps1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is alternatively spliced in the 5' region and contains an additional in-frame exon compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC155307, AK142355, CN667090, DV651380
    Consensus CDS
    CCDS79371.1
    UniProtKB/TrEMBL
    Q3UQJ9, V9GXE9
    Related
    ENSMUSP00000139115.2, ENSMUST00000183997.8
    Conserved Domains (2) summary
    smart00401
    Location:706749
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:710766
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  3. NM_032000.2NP_114389.2  zinc finger transcription factor Trps1 isoform 2

    See identical proteins and their annotated locations for NP_114389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' end and uses an in-frame, downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC142245, AC155307, DV651380
    Consensus CDS
    CCDS27460.1
    UniProtKB/TrEMBL
    G3UW90
    Related
    ENSMUSP00000129779.2, ENSMUST00000165201.9
    Conserved Domains (1) summary
    cd00202
    Location:895951
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    50518149..50754027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159653.1XP_036015546.1  zinc finger transcription factor Trps1 isoform X6

    Related
    ENSMUSP00000138905.2, ENSMUST00000184885.8
    Conserved Domains (1) summary
    cd00202
    Location:695751
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  2. XM_011245780.4XP_011244082.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244082.1

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  3. XM_036159648.1XP_036015541.1  zinc finger transcription factor Trps1 isoform X2

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  4. XM_036159651.1XP_036015544.1  zinc finger transcription factor Trps1 isoform X4

    Conserved Domains (1) summary
    cd00202
    Location:706762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  5. XM_036159652.1XP_036015545.1  zinc finger transcription factor Trps1 isoform X6

    Conserved Domains (1) summary
    cd00202
    Location:695751
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  6. XM_030248828.2XP_030104688.1  zinc finger transcription factor Trps1 isoform X4

    Conserved Domains (1) summary
    cd00202
    Location:706762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  7. XM_011245776.4XP_011244078.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244078.1

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  8. XM_036159650.1XP_036015543.1  zinc finger transcription factor Trps1 isoform X4

    Conserved Domains (1) summary
    cd00202
    Location:706762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  9. XM_036159649.1XP_036015542.1  zinc finger transcription factor Trps1 isoform X3

    Conserved Domains (1) summary
    cd00202
    Location:895951
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  10. XM_011245778.4XP_011244080.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244080.1

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  11. XM_006521560.4XP_006521623.1  zinc finger transcription factor Trps1 isoform X1

    Conserved Domains (1) summary
    cd00202
    Location:910966
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  12. XM_030248826.2XP_030104686.1  zinc finger transcription factor Trps1 isoform X2

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  13. XM_006521563.4XP_006521626.1  zinc finger transcription factor Trps1 isoform X5

    Conserved Domains (1) summary
    cd00202
    Location:699755
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  14. XM_036159645.1XP_036015538.1  zinc finger transcription factor Trps1 isoform X2

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  15. XM_011245777.3XP_011244079.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244079.1

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  16. XM_036159647.1XP_036015540.1  zinc finger transcription factor Trps1 isoform X2

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  17. XM_036159646.1XP_036015539.1  zinc finger transcription factor Trps1 isoform X2

    Conserved Domains (1) summary
    cd00202
    Location:906962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
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