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Gpr137b G protein-coupled receptor 137B [ Mus musculus (house mouse) ]

Gene ID: 83924, updated on 26-Sep-2022

Summary

Official Symbol
Gpr137bprovided by MGI
Official Full Name
G protein-coupled receptor 137Bprovided by MGI
Primary source
MGI:MGI:1891463
See related
Ensembl:ENSMUSG00000021306 AllianceGenome:MGI:1891463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tm7sf1; D13Abb1e; C730041E01
Summary
Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of macrophage activation. Located in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 66.3), lung adult (RPKM 28.3) and 20 other tissues See more
Orthologs
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Genomic context

See Gpr137b in Genome Data Viewer
Location:
13 A1; 13 5.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13528035..13568250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13357620..13393644, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene ERO1-like beta pseudogene Neighboring gene embryonic H3 histone Neighboring gene nidogen 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integral membrane protein GPR137B
Names
transmembrane 7 superfamily member 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031999.2NP_114388.2  integral membrane protein GPR137B

    See identical proteins and their annotated locations for NP_114388.2

    Status: VALIDATED

    Source sequence(s)
    AK080884, BB847916, BU758113
    Consensus CDS
    CCDS26243.1
    UniProtKB/Swiss-Prot
    Q8BNQ3
    UniProtKB/TrEMBL
    A0A0R4J022
    Related
    ENSMUSP00000021738.9, ENSMUST00000021738.10
    Conserved Domains (1) summary
    TIGR03022
    Location:65176
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    13528035..13568250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516805.5XP_006516868.1  integral membrane protein GPR137B isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VLJ5
    Related
    ENSMUSP00000152434.2, ENSMUST00000223093.2
    Conserved Domains (1) summary
    TIGR03022
    Location:65176
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

RNA

  1. XR_382078.3 RNA Sequence